Therapy Detail

Therapy Name Prexasertib + Ralimetinib
Synonym
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Prexasertib LY2606368|IC-83 CHK1 Inhibitor 14 Prexasertib (LY2606368) inhibits checkpoint kinase 1 (Chk1), which may result in accumulation of DNA damage and decreased tumor growth (PMID: 26141948, PMID: 28270495).
Ralimetinib LY2228820 p38-alpha Inhibitor 1 Ralimetinib (LY2228820) is a selective ATP competitive inhibitor of p38 MAPK alpha (MAPK14) and beta (MAPK11), which inhibits tumor growth (PMID: 26581242, PMID: 24356814).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT02860780 Phase I Prexasertib + Ralimetinib A Study of Prexasertib (LY2606368) in Combination With Ralimetinib in Participants With Advanced or Metastatic Cancer Completed