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Drug Name Pegaspargase
Trade Name Oncaspar
Synonyms PEG-asparaginase|PEG-ASP
Drug Descriptions

Oncaspar (pegaspargase) is a pegylated version of L-asparaginase, which converts L-asparagine to ammonia and L-aspartic acid, reducing available asparagine resulting in decreased protein synthesis, inhibition of tumor cell proliferation, and increased apoptosis (NCI Drug Dictionary).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Leucovorin + Methotrexate + Pegaspargase + Thioguanine + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Leucovorin Methotrexate Pegaspargase Thioguanine Vincristine 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Leucovorin + Methotrexate + Pegaspargase + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Leucovorin Methotrexate Pegaspargase Vincristine 0 0
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Pegaspargase + Thioguanine + Vincristine Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Pegaspargase Thioguanine Vincristine 0 1
Cyclophosphamide + Cytarabine + Leucovorin + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Cyclophosphamide Cytarabine Leucovorin Mercaptopurine Methotrexate Pegaspargase Vincristine 0 1
Cyclophosphamide + Cytarabine + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Cyclophosphamide Cytarabine Mercaptopurine Methotrexate Pegaspargase Vincristine 0 2
Cyclophosphamide + Cytarabine + Mercaptopurine + Pegaspargase Cyclophosphamide Cytarabine Mercaptopurine Pegaspargase 0 1
Cyclophosphamide + Cytarabine + Mercaptopurine + Pegaspargase + Vincristine Cyclophosphamide Cytarabine Mercaptopurine Pegaspargase Vincristine 0 0
Cyclophosphamide + Cytarabine + Methotrexate + Pegaspargase + Thioguanine + Vincristine Cyclophosphamide Cytarabine Methotrexate Pegaspargase Thioguanine Vincristine 0 1
Cyclophosphamide + Dexamethasone + Doxorubicin + Nelarabine + Pegaspargase + Venetoclax + Vincristine Cyclophosphamide Dexamethasone Doxorubicin Nelarabine Pegaspargase Venetoclax Vincristine 0 1
Cyclophosphamide + Methotrexate + Pegaspargase + Vincristine Cyclophosphamide Methotrexate Pegaspargase Vincristine 0 2
Cyclophosphamide + Pegaspargase + Vincristine Cyclophosphamide Pegaspargase Vincristine 0 0
Cytarabine + Daunorubicin + Dexamethasone + Hydrocortisone + Methotrexate + Pegaspargase + Prednisolone + Vincristine Cytarabine Daunorubicin Dexamethasone Hydrocortisone Methotrexate Pegaspargase Prednisolone Vincristine 0 1
Cytarabine + Daunorubicin + Dexamethasone + Hydrocortisone + Pegaspargase + Thioguanine + Vincristine sulfate liposome Cytarabine Daunorubicin Dexamethasone Hydrocortisone Pegaspargase Thioguanine Vincristine sulfate liposome 0 1
Cytarabine + Daunorubicin + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Cytarabine Daunorubicin Dexamethasone Methotrexate Pegaspargase Vincristine 0 1
Cytarabine + Daunorubicin + inotuzumab ozogamicin + Methotrexate + Pegaspargase + Prednisone + Vincristine Cytarabine Daunorubicin Methotrexate Pegaspargase Prednisone Vincristine inotuzumab ozogamicin 0 0
Cytarabine + Daunorubicin + Methotrexate + Pegaspargase + Prednisolone + Vincristine Cytarabine Daunorubicin Methotrexate Pegaspargase Prednisolone Vincristine 0 1
Cytarabine + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Cytarabine Dexamethasone Methotrexate Pegaspargase Vincristine 0 1
Cytarabine + Dexamethasone + Pegaspargase + Vincristine Cytarabine Dexamethasone Pegaspargase Vincristine 0 0
Cytarabine + Doxorubicin + Palbociclib + Pegaspargase + Prednisolone + Vincristine Cytarabine Doxorubicin Palbociclib Pegaspargase Prednisolone Vincristine 0 1
Cytarabine + Doxorubicin + Palbociclib + Pegaspargase + Prednisone + Vincristine Cytarabine Doxorubicin Palbociclib Pegaspargase Prednisone Vincristine 0 1
Cytarabine + Hydrocortisone + Leucovorin + Mercaptopurine + Pegaspargase Cytarabine Hydrocortisone Leucovorin Mercaptopurine Pegaspargase 0 1
Cytarabine + Leucovorin + Methotrexate + Pegaspargase + Vincristine Cytarabine Leucovorin Methotrexate Pegaspargase Vincristine 0 1
Cytarabine + Methotrexate + Nelarabine + Pegaspargase + Venetoclax Cytarabine Methotrexate Nelarabine Pegaspargase Venetoclax 0 1
Daunorubicin + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Daunorubicin Dexamethasone Methotrexate Pegaspargase Vincristine 0 1
Daunorubicin + inotuzumab ozogamicin + Pegaspargase + Prednisone + Vincristine Daunorubicin Pegaspargase Prednisone Vincristine inotuzumab ozogamicin 0 1
Daunorubicin + Pegaspargase + Vincristine Daunorubicin Pegaspargase Vincristine 0 1
Dexamethasone + Doxorubicin + Methotrexate + Pegaspargase + Vincristine Dexamethasone Doxorubicin Methotrexate Pegaspargase Vincristine 0 2
Dexamethasone + Doxorubicin + MLN4924 + Pegaspargase + Vincristine Dexamethasone Doxorubicin MLN4924 Pegaspargase Vincristine 0 1
Dexamethasone + Doxorubicin + Pegaspargase + Vincristine Dexamethasone Doxorubicin Pegaspargase Vincristine 0 2
Dexamethasone + Methotrexate + Mitoxantrone + Pegaspargase + Vincristine sulfate liposome Dexamethasone Methotrexate Mitoxantrone Pegaspargase Vincristine sulfate liposome 0 1
Dexamethasone + Methotrexate + Pegaspargase + Vincristine sulfate liposome Dexamethasone Methotrexate Pegaspargase Vincristine sulfate liposome 0 1
Leucovorin + Pegaspargase + Vincristine Leucovorin Pegaspargase Vincristine 0 1
Methotrexate + Pegaspargase Methotrexate Pegaspargase 0 1
Methotrexate + Pegaspargase + Venetoclax Methotrexate Pegaspargase Venetoclax 0 1
Methotrexate + Pegaspargase + Vincristine Methotrexate Pegaspargase Vincristine 0 2
Nelarabine + Pegaspargase Nelarabine Pegaspargase 0 1
Nelarabine + Pegaspargase + Venetoclax Nelarabine Pegaspargase Venetoclax 0 1
Pegaspargase Pegaspargase 0 14


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