Therapy Detail

Therapy Name Vincristine + Pegaspargase + Daunorubicin
Therapy Description


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Drug Name Trade Name Synonyms Drug Classes Drug Description
Daunorubicin Cerubidine Rubidomycin|daunomycin hydrochloride|rubomycin C|Acetyladriamycin Chemotherapy - Anthracycline 11 Cerubidine (daunorubicin) is an anthracycline, which inhibits DNA replication and repair (NCI Drug Dictionary). Cerubidine (daunorubicin) is FDA approved for AML and MLL (
Pegaspargase Oncaspar PEG-asparaginase|PEG-ASP Oncaspar (pegaspargase) is a pegylated version of L-asparaginase, which converts L-asparagine to ammonia and L-aspartic acid, reducing available asparagine resulting in decreased protein synthesis, inhibition of tumor cell proliferation, and increased apoptosis (NCI Drug Dictionary).
Vincristine Oncovin 22-Oxovincaleukoblastine Oncovin (vincristine) binds microtubules and prevents mitotic spindle formation, resulting in cell-cycle arrest (NCI Drug Dictionary).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status
NCT00549848 Phase III Vincristine + Pegaspargase + Daunorubicin Cytarabine Mercaptopurine Thioguanine Clofarabine + Etoposide + Cyclophosphamide Methotrexate Dasatinib Doxorubicin Dexamethasone Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia Active, not recruiting