Drug Detail


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Drug Name JNJ-75276617
Trade Name
Synonyms JNJ 75276617|JNJ75276617
Drug Descriptions

JNJ-75276617 inhibits the interaction between menin and MLL, leading to decreased expression of target genes, potentially resulting in inhibition of cell proliferation of tumor cells harboring gene rearrangements, duplications or amplifications in KMT2A or gene alterations in NPM1 (NCI Drug Dictionary).

DrugClasses MEN1-KMT2A Inhibitor 7
CAS Registry Number NA
NCIT ID C179561


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + JNJ-75276617 Azacitidine JNJ-75276617 1 1
Azacitidine + JNJ-75276617 + Venetoclax Azacitidine JNJ-75276617 Venetoclax 1 1
Cytarabine + Dexamethasone + Fludarabine + JNJ-75276617 + Pegaspargase + Vincristine Sulfate Cytarabine Dexamethasone Fludarabine JNJ-75276617 Pegaspargase Vincristine Sulfate 0 1
JNJ-75276617 JNJ-75276617 0 1
JNJ-75276617 + Venetoclax JNJ-75276617 Venetoclax 1 1

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