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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cytarabine Cytosar-U Ara-C Cytosar-U (cytarabine) is a cytidine analog that, when incorporated into DNA, inhibits DNA synthesis and repair (PMID: 32524309).
Dexamethasone Adexone Desametasone
Hydrocortisone Cortisol
Methotrexate Abitrexate Amethopterin Chemotherapy - Antimetabolite 14 Methotrexate is an antimetabolite, which inhibits DHFR resulting in decreased immune function and antineoplastic activity and is FDA approved for psoriasis, RA, and several cancers including choriocarcinoma, AML, lung, head and neck and epidermoid (FDA.gov).
Navitoclax ABT-263 BCL-XL inhibitor 14 BCL2 inhibitor 27 Navitoclax (ABT-263) is a BCL2, BCL-XL, and BCL-W inhibitor, which may enhance the efficacy of chemotherapeutics (PMID: 25787766, PMID: 32513939).
Pegaspargase Oncaspar PEG-asparaginase|PEG-ASP Oncaspar (pegaspargase) is a pegylated version of L-asparaginase, which converts L-asparagine to ammonia and L-aspartic acid, reducing available asparagine resulting in decreased protein synthesis, inhibition of tumor cell proliferation, and increased apoptosis (NCI Drug Dictionary).
Venetoclax Venclexta ABT-199|RG7601|GDC-0199|ABT119|Venclyxto BCL2 inhibitor 27 Venclexta (venetoclax) is a BH3-mimetic that binds to and inhibits BCL2, resulting in increased tumor cell apoptosis (PMID: 26589495, PMID: 25048785). Venclexta (venetoclax) is FDA approved for use in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), and in combination with chemotherapy in patients 75 years old or older with newly-diagnosed acute myeloid leukemia (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05192889 Phase Ib/II Dexamethasone + Pegaspargase + Vincristine Sulfate Blinatumomab + Cytarabine + Dexamethasone + Hydrocortisone + Methotrexate + Venetoclax Cyclophosphamide + Cytarabine + Dexamethasone + Etoposide + Hydrocortisone + Leucovorin + Mercaptopurine + Methotrexate + Vincristine Sulfate Cytarabine + Dexamethasone + Hydrocortisone + Mercaptopurine + Methotrexate + Vincristine Sulfate Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Methotrexate + Navitoclax + Pegaspargase + Venetoclax Dasatinib + Dexamethasone + Pegaspargase + Vincristine Sulfate Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Mercaptopurine + Methotrexate + Vincristine Sulfate Cytarabine + Dexamethasone + Hydrocortisone + Leucovorin + Methotrexate + Navitoclax + Pegaspargase + Venetoclax + Vincristine Sulfate Cyclophosphamide + Cytarabine + Dasatinib + Dexamethasone + Etoposide + Hydrocortisone + Leucovorin + Mercaptopurine + Methotrexate + Vincristine Sulfate Cytarabine + Dexamethasone + Hydrocortisone + Methotrexate + Navitoclax + Pegaspargase + Venetoclax Cytarabine + Hydrocortisone + Leucovorin + Mercaptopurine + Methotrexate Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Leucovorin + Methotrexate + Navitoclax + Pegaspargase + Venetoclax + Vincristine Sulfate Blinatumomab + Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Methotrexate + Venetoclax Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax Recruiting USA 0


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