Drug Detail


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Drug Name Dinutuximab beta
Trade Name
Synonyms ch14.18/CHO|APN311|APN-311|APN 311|Qarziba
Drug Descriptions

Dinutuximab beta (ch14.18/CHO) is biosimilar of the anti-GD2 antibody Unituxin (dinutuximab) produced in CHO cells, with a different glycosylation pattern than dinutuximab, which potentially induces antibody-dependent and complement-dependent cytotoxicity against GD2-expressing tumor cells, and reduces liver metastasis (PMID: 30613134, PMID: 15950727).

CAS Registry Number NA


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Aldesleukin + Dinutuximab beta Aldesleukin Dinutuximab beta 0 1
Cyclophosphamide + Dinutuximab beta + Topotecan Cyclophosphamide Dinutuximab beta Topotecan 0 1
Dinutuximab beta Dinutuximab beta 0 2
Dinutuximab beta + Nivolumab Dinutuximab beta Nivolumab 0 1
Dinutuximab beta + Temozolomide Dinutuximab beta Temozolomide 0 1
Dinutuximab beta + Temozolomide + Topotecan Dinutuximab beta Temozolomide Topotecan 0 1

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