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|Therapy Name||GSK2256098 + Topotecan|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|GSK2256098||GSK-2256098|GSK 2256098||FAK inhibitor 15||GSK2256098 is an inhibitor of focal adhesion kinase (FAK), which blocks integrin signaling and therefore, has antitumor activities (PMID: 21787277, PMID: 30992546).|
|Topotecan||Hycamtin||Topotecan Hcl||Topotecan binds to topoisomerase I and stablizes complexes with DNA, resulting in decreased repair of DNA single-strand breaks, and potentially leading to cell death (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PTEN mutant||uterine cancer||sensitive||GSK2256098 + Topotecan||Preclinical||Actionable||In a preclinical study, uterine cancer cells harboring a PTEN mutation were more sensitive to the combination of GSK2256098 and Hycamtin (topotecan) than uterine cancer cells wild-type for PTEN, resulting in decreased tumor growth in culture and in mouse models (PMID: 25833835).||25833835|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|