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Drug Name LCL161
Trade Name
Synonyms
Drug Descriptions

LCL161 is a SMAC mimetic that inhibits Inhibitor of Apoptosis Protein (IAP) family proteins, potentially leading to increased tumor cell death (PMID: 21681929, PMID: 24976294).

DrugClasses SMAC Mimetic 8

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cyclophosphamide + LCL161 Cyclophosphamide LCL161 1 1
LCL161 LCL161 0 1
LCL161 + Paclitaxel LCL161 Paclitaxel 1 0
LCL161 + Spartalizumab LCL161 Spartalizumab 0 2
LCL161 + Topotecan LCL161 Topotecan 0 1


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