Drug Detail


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Drug Name LCL161
Trade Name
Synonyms LCL-161|LCL 161
Drug Descriptions

LCL161 is a SMAC mimetic that inhibits Inhibitor of Apoptosis Protein (IAP) family proteins, potentially leading to increased tumor cell death (PMID: 21681929, PMID: 24976294, PMID: 25113756).

DrugClasses SMAC Mimetic 8
CAS Registry Number 1005342-46-0
NCIT ID C91079


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cyclophosphamide + LCL161 Cyclophosphamide LCL161 0 1
LCL161 LCL161 0 1
LCL161 + Paclitaxel LCL161 Paclitaxel 0 0
LCL161 + Spartalizumab LCL161 Spartalizumab 0 2
LCL161 + Topotecan LCL161 Topotecan 0 1

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