Drug Detail


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Drug Name ALRN-6924
Trade Name
Synonyms CS-0044703
Drug Descriptions

ALRN-6924 (CS-0044703) binds to MDM2 and MDM4 (MDMX) and prevents their interaction with p53, resulting in restoration of p53 activity and potentially leading to increased tumor cell death (PMID: 29643228, PMID: 30253242).

DrugClasses MDM2 Inhibitor 22 MDM4 inhibitor 8
CAS Registry Number NA
NCIT ID C118669


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Therapy Name Drugs Efficacy Evidence Clinical Trials
ALRN-6924 ALRN-6924 9 3
ALRN-6924 + Carboplatin + Pemetrexed Disodium ALRN-6924 Carboplatin Pemetrexed Disodium 0 1
ALRN-6924 + Cyclophosphamide + Docetaxel + Doxorubicin ALRN-6924 Cyclophosphamide Docetaxel Doxorubicin 0 1
ALRN-6924 + Cytarabine ALRN-6924 Cytarabine 0 2
ALRN-6924 + Paclitaxel ALRN-6924 Paclitaxel 0 1
ALRN-6924 + Topotecan ALRN-6924 Topotecan 0 1

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