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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|ALRN-6924||MDM2 Inhibitor 19 MDM4 inhibitor 8||ALRN-6924 binds to MDM2 and MDM4 (MDMX) and prevents their interaction with p53, resulting in restoration of p53 activity and potentially leading to increased tumor cell death (PMID: 29643228).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02264613||Phase Ib/II||ALRN-6924||Safety Study of ALRN-6924 in Patients With Advanced Solid Tumors||Completed|
|NCT02909972||Phase I||ALRN-6924 + Cytarabine ALRN-6924||Safety Study of ALRN-6924 in Patients With Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome||Completed|
|NCT03654716||Phase I||ALRN-6924 + Cytarabine ALRN-6924||Phase 1 Study of the Dual MDM2/MDMX Inhibitor ALRN-6924 in Pediatric Cancer||Recruiting|