Disease Detail

ID DOID:3382
Name liposarcoma
Definition A lipomatous cancer that arises in fat cells in deep soft tissue retroperitoneum and the extremities.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer musculoskeletal system cancer connective tissue cancer lipomatous cancer liposarcoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Unknown unknown MGCD516 liposarcoma not applicable detail...
Unknown unknown Dasatinib liposarcoma not applicable detail...
Unknown unknown Pazopanib liposarcoma not applicable detail...
Unknown unknown Anlotinib liposarcoma not applicable detail...
Unknown unknown Palbociclib liposarcoma not applicable detail...
Unknown unknown Alvocidib + Doxorubicin liposarcoma not applicable detail...
Unknown unknown Alisertib liposarcoma not applicable detail...
Unknown unknown Regorafenib liposarcoma no benefit detail...
TP53 wild-type MK-8242 liposarcoma predicted - sensitive detail...
Unknown unknown Pembrolizumab liposarcoma not applicable detail...
TP53 wild-type ALRN-6924 liposarcoma sensitive detail...
Unknown unknown Selinexor liposarcoma not applicable detail...
Unknown unknown Doxorubicin + Selinexor liposarcoma not applicable detail...
Unknown unknown Trabectedin liposarcoma not applicable detail...
Unknown unknown Doxorubicin + Nilotinib liposarcoma not applicable detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT00356031 Phase II Bevacizumab Bevacizumab and Radiation Therapy for Sarcomas Completed
NCT02048371 Phase II Regorafenib A Blanket Protocol to Study Oral Regorafenib in Patients With Refractory Liposarcoma, Osteogenic Sarcoma, and Ewing/Ewing-like Sarcomas Recruiting
NCT02210104 Phase I Ipilimumab Cyclophosphamide Adoptive Therapy Using Antigen-Specific CD4 T-Cells Withdrawn
NCT02301039 Phase II Pembrolizumab A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas Active, not recruiting
NCT02343172 Phase Ib/II HDM201 + Ribociclib Study of Safety and Efficacy of HDM201 in Combination With LEE011 in Patients With Liposarcoma Active, not recruiting
NCT02357810 Phase II Pazopanib + Topotecan Pazopanib Hydrochloride and Topotecan Hydrochloride in Treating Patients With Metastatic Soft Tissue and Bone Sarcomas Recruiting
NCT02606461 Phase II Selinexor KCP-330-020 SEAL (Selinexor in Advanced Liposarcoma) (SEAL) Recruiting
NCT02846987 Phase II Abemaciclib Study of Abemaciclib in Dedifferentiated Liposarcoma Recruiting
NCT02978859 Phase II MGCD516 MGCD516 in Advanced Liposarcoma and Other Soft Tissue Sarcomas Recruiting
NCT03009201 Phase I Doxorubicin + Ribociclib Ribociclib and Doxorubicin Hydrochloride in Treating Patients Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery Recruiting
NCT03074318 Phase Ib/II Avelumab + Trabectedin Avelumab and Trabectedin in Treating Patients With Liposarcoma or Leiomyosarcoma That is Metastatic or Cannot Be Removed by Surgery Suspended
NCT03114527 Phase II Everolimus + Ribociclib Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS) Recruiting
NCT03190174 Phase Ib/II Nab-Rapamycin + Nivolumab Nivolumab (Opdivo) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma Recruiting
NCT03307616 Phase II Ipilimumab + Nivolumab Nivolumab Study of Neoadjuvant Checkpoint Blockade in Patients With Surgically Resectable Undifferentiated Pleomorphic Sarcoma and Dedifferentiated Liposarcoma Recruiting
NCT03719430 Phase II APX005M + Doxorubicin + Olaratumab APX005M, Doxorubicin, Olaratumab in Advanced Sarcoma Recruiting
NCT03880123 Phase I Ixazomib + Selinexor Selinexor in Combination With Ixazomib for the Treatment of Advanced Sarcoma Not yet recruiting
NCT03899805 Phase II Eribulin + Pembrolizumab A Phase II Study of Eribulin and Pembrolizumab in Soft Tissue Sarcomas Not yet recruiting