Therapy Detail

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Therapy Name Trabectedin
Synonyms
Therapy Description

Yondelis (trabectedin) is a marine-derived alkaloid that binds to DNA and induces DNA strand breaks, leading to cell cycle arrest and cell death in tumor cells (PMID: 24755886). Yondelis (trabectedin) is FDA approved for metastatic liposarcoma or leiomyosarcoma who received prior anthracycline treatment (FDA.gov).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Trabectedin Yondelis ET-743 Chemotherapy - Alkylating 16 Yondelis (trabectedin) is a marine-derived alkaloid that binds to DNA and induces DNA strand breaks, leading to cell cycle arrest and cell death in tumor cells (PMID: 24755886). Yondelis (trabectedin) is FDA approved for metastatic liposarcoma or leiomyosarcoma who received prior anthracycline treatment (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03056599 Phase I Pembrolizumab Avelumab Interferon gamma Olaratumab Trabectedin Nivolumab Gemcitabine Interferon alpha-2b Doxorubicin Atezolizumab Eribulin Ipilimumab Durvalumab Aldesleukin Bortezomib Docetaxel Precise Local Injection of Anti-cancer Drugs Using Presage's CIVO™ Device in Soft Tissue Sarcoma Completed USA 0
NCT02275286 Phase Ib/II Trabectedin Trabectedin Plus Radiotherapy in Soft Tissue Sarcoma Patients (TRASTS) Recruiting ITA | FRA | ESP 0
NCT03023124 Phase II Trabectedin Dacarbazine + Doxorubicin Study With Trabectedin Versus Adriamycin Plus Dacarbazine, in Patients With Advanced Solitary Fibrous Tumor (STRADA) Recruiting ITA 0
NCT04979442 Phase III Trabectedin Milademetan Treatment of Milademetan Versus Trabectedin in Patient With Dedifferentiated Liposarcoma (MANTRA) (MANTRA) Active, not recruiting USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT 6
NCT04305548 Phase II Trabectedin Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma (ISG-MCS) Active, not recruiting ITA 0
NCT03397186 Phase II Trabectedin Immune Changes Following Trabectedin in Patients With Metastatic or Unresectable Sarcoma Withdrawn USA 0
NCT02359474 Phase II Trabectedin Hyper-Thermia Enhanced Anti-tumor Efficacy of Trabectedin (HyperTET) Active, not recruiting DEU 0
NCT04383119 Phase II Gemcitabine Trabectedin Trial in Patients With Metastatic or Locally Advanced Leiomyosarcoma (ISG-ARTICLE) Active, not recruiting ITA 0
NCT03838744 Phase II Olaparib + Trabectedin Trabectedin Randomized Trial in Advanced, Metastatic or Unresectable Soft Tissue Sarcoma After Failure of Standard Treatments. (TOMAS2) Recruiting ITA 0


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