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Drug Name Trabectedin
Trade Name Yondelis
Synonyms ET-743
Drug Descriptions

Yondelis (trabectedin) is a marine-derived alkaloid that binds to DNA and induces DNA strand breaks, leading to cell cycle arrest and cell death in tumor cells (PMID: 24755886). Yondelis (trabectedin) is FDA approved for metastatic liposarcoma or leiomyosarcoma who received prior anthracycline treatment (FDA.gov).

DrugClasses Chemotherapy - Alkylating 18
CAS Registry Number 114899-77-3
NCIT ID C1691

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Trabectedin Avelumab Trabectedin 0 1
Cisplatin + Trabectedin Cisplatin Trabectedin 0 0
Dacarbazine + Gemcitabine + Trabectedin Dacarbazine Gemcitabine Trabectedin 0 1
Dexamethasone + Trabectedin Dexamethasone Trabectedin 0 1
Dovitinib + Trabectedin Dovitinib Trabectedin 1 0
Doxorubicin + Olaratumab + Trabectedin Doxorubicin Olaratumab Trabectedin 0 1
Doxorubicin + Trabectedin Doxorubicin Trabectedin 0 1
Durvalumab + Trabectedin Durvalumab Trabectedin 0 1
Gemcitabine + Trabectedin Gemcitabine Trabectedin 0 0
Infigratinib + Trabectedin Infigratinib Trabectedin 1 0
Ipilimumab + Nivolumab + Trabectedin Ipilimumab Nivolumab Trabectedin 0 1
Irinotecan + Trabectedin Irinotecan Trabectedin 0 1
Nivolumab + Talimogene laherparepvec + Trabectedin Nivolumab Talimogene laherparepvec Trabectedin 0 1
Obatoclax + Trabectedin Obatoclax Trabectedin 0 0
Olaparib + Trabectedin Olaparib Trabectedin 0 3
Pazopanib + Trabectedin Pazopanib Trabectedin 0 0
PD173074 + Trabectedin PD173074 Trabectedin 1 0
Pegylated liposomal doxorubicin + Trabectedin Pegylated liposomal doxorubicin Trabectedin 0 1
Pioglitazone + Trabectedin Pioglitazone Trabectedin 0 1
Trabectedin Trabectedin 0 10
Trabectedin + tTF-NGR Trabectedin tTF-NGR 0 0
Trabectedin + Venetoclax Trabectedin Venetoclax 0 1


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