Drug Detail


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Drug Name Olaratumab
Trade Name Lartruvo
Synonyms IMC-3G3
Drug Descriptions

Lartruvo (olaratumab) is a monoclonal antibody that targets PDGFR-alpha and prevents ligand binding, potentially leading to decreased angiogenesis and reduced proliferation of tumor cells (PMID: 27291997). Lartruvo (olaratumab) in combination with doxorubicin is FDA approved for patients with soft tissue sarcoma (FDA.gov).

DrugClasses PDGFRA Antibody 2
CAS Registry Number 1024603-93-7
NCIT ID C79825


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Therapy Name Drugs Efficacy Evidence Clinical Trials
APX005M + Doxorubicin + Olaratumab APX005M Doxorubicin Olaratumab 0 1
Doxorubicin + Ifosfamide + Mesna + Olaratumab Doxorubicin Ifosfamide Mesna Olaratumab 0 1
Doxorubicin + Olaratumab Doxorubicin Olaratumab 1 2
Doxorubicin + Olaratumab + Trabectedin Doxorubicin Olaratumab Trabectedin 0 1
Gemcitabine + Nab-paclitaxel + Olaratumab Gemcitabine Nab-paclitaxel Olaratumab 0 1
Olaratumab Olaratumab 0 5
Olaratumab + Pembrolizumab Olaratumab Pembrolizumab 0 1

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