Drug Detail


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Drug Name Dovitinib
Trade Name
Synonyms TKI258|CHIR-258
Drug Descriptions

Dovitinib (TKI258) targets multiple receptor tyrosine kinases including Flt3, c-Kit, CSF1R, FGFR 1-4, VEGFR 1-3, and PDGFR alpha and beta, potentially resulting in decreased tumor growth (PMID: 15598814, PMID: 25219510, PMID: 23658459, PMID: 16033847).

DrugClasses CSF1R Inhibitor 28 FGFR Inhibitor (Pan) 26 FLT3 Inhibitor 65 KIT Inhibitor 57 PDGFR Inhibitor (Pan) 30 VEGFR Inhibitor (Pan) 36
CAS Registry Number 405169-16-6
NCIT ID C76199


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Binimetinib + Dovitinib Binimetinib Dovitinib 1 0
Dovitinib Dovitinib 100 16
Dovitinib + E7449 Dovitinib E7449 0 1
Dovitinib + Fluvoxamine Dovitinib Fluvoxamine 0 1
Dovitinib + Fulvestrant Dovitinib Fulvestrant 0 1
Dovitinib + Gemcitabine + Nab-paclitaxel Dovitinib Gemcitabine Nab-paclitaxel 0 1
Dovitinib + Trabectedin Dovitinib Trabectedin 1 0

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