Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Dovitinib
Trade Name
Synonyms TKI258|CHIR-258
Drug Descriptions

Dovitinib (TKI258) targets multiple receptor tyrosine kinases including Flt3, c-Kit, CSF1R, FGFR 1-4, VEGFR 1-3, and PDGFR alpha and beta, potentially resulting in decreased tumor growth (PMID: 15598814, PMID: 25219510, PMID: 23658459, PMID: 16033847).

DrugClasses CSF1R Inhibitor 28 FGFR Inhibitor (Pan) 25 FLT3 Inhibitor 65 KIT Inhibitor 57 PDGFR Inhibitor (Pan) 30 VEGFR Inhibitor (Pan) 36
CAS Registry Number 405169-16-6
NCIT ID C76199

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Binimetinib + Dovitinib Binimetinib Dovitinib 1 0
Dovitinib Dovitinib 100 16
Dovitinib + E7449 Dovitinib E7449 0 1
Dovitinib + Fluvoxamine Dovitinib Fluvoxamine 0 1
Dovitinib + Fulvestrant Dovitinib Fulvestrant 0 1
Dovitinib + Gemcitabine + Nab-paclitaxel Dovitinib Gemcitabine Nab-paclitaxel 0 1
Dovitinib + Trabectedin Dovitinib Trabectedin 1 0


Additional content available in CKB BOOST