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Drug Name Dovitinib
Trade Name
Synonyms TKI258|CHIR-258
Drug Descriptions

Dovitinib (TKI258) targets multiple receptor tyrosine kinases including Flt3, c-Kit, CSF1R, FGFR 1-4, VEGFR 1-3, and PDGFR alpha and beta, potentially resulting in decreased tumor growth (PMID: 15598814, PMID: 25219510, PMID: 23658459, PMID: 16033847).

DrugClasses CSF1R Inhibitor 23 FGFR Inhibitor (Pan) 18 FLT3 Inhibitor 54 KIT Inhibitor 50 PDGFR Inhibitor (Pan) 27 VEGFR Inhibitor (Pan) 32

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Dovitinib Dovitinib 55 16
Dovitinib + Fluvoxamine Dovitinib Fluvoxamine 0 1
Dovitinib + Fulvestrant Dovitinib Fulvestrant 0 1
Dovitinib + Gemcitabine + Nab-paclitaxel Dovitinib Gemcitabine Nab-paclitaxel 0 1
Dovitinib + Trabectedin Dovitinib Trabectedin 1 0


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