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Drug Name E7449
Trade Name
Synonyms 2X-121
Drug Descriptions

E7449 (2X-121) binds to and inhibits PARP1 and PARP2, as well as TNKS1 and TNKS2, potentially resulting in increased sensitivity to DNA damaging agents and decreased growth of tumor cells with defective DNA damage repair (PMID: 26513298, PMID: 32523090).

DrugClasses PARP Inhibitor (Pan) 19 Tankyrase Inhibitor 9

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + E7449 Carboplatin E7449 1 0
E6201 + E7449 E6201 E7449 0 0
E7449 E7449 5 1
E7449 + Temozolomide E7449 Temozolomide 1 0


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