Therapy Detail

Therapy Name Nivolumab + Ipilimumab
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Ipilimumab Yervoy BMS-734016 CTLA4 Antibody 8 Immune Checkpoint Inhibitor 99 Yervoy (ipilimumab) is an antibody that binds to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), causing increased T-cell activation (NCI Drug Dictionary). Yervoy (ipilimumab) is FDA approved for use in patients with metastatic melanoma, including patients 12 years or older, and in combination with Opdivo (nivolumab) for intermediate or poor-risk renal cell carcinoma and microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (FDA.gov).
Nivolumab Opdivo MDX-1106|BMS-936558 Immune Checkpoint Inhibitor 99 PD-L1/PD-1 antibody 48 Opdivo (nivolumab) is an antibody that targets PD-1 (PDCD1), which results in increased T-cell activation and enhanced anti-tumor immune response (NCI Drug Dictionary). Opdivo (nivolumab) is FDA approved for the treatment of metastatic melanoma, squamous NSCLC, metastatic small cell lung cancer, renal cell carcinoma, head and neck squamous cell carcinoma, urothelial carcinoma, Hodgkin's lymphoma, hepatocellular carcinoma, and for dMMR or MSI-H colorectal cancer as a single agent or in combination with Yervoy (ipilimumab) (FDA.gov).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown stomach cancer not applicable Nivolumab + Ipilimumab Phase Ib/II Actionable In a Phase I/II trial, Opdivo (nivolumab), alone or incombination with Yervoy (ipilimumab), demonstrated safety and efficacy in patients with chemotherapy-refractory gastric cancer, resulted in a disease control rate of 38% (61/160) (J Clin Oncol 34, 2016 (suppl; abstr 4010)). detail...
Unknown unknown melanoma not applicable Nivolumab + Ipilimumab Phase II Actionable In a Phase II trial, the combination of Opdivo (nivolumab) and Yervoy (ipilimumab) resulted in improved overall response rate (ORR) and pathologic complete response rate (pCR) compared to Opdivo (nivolumab) monotherapy in patients with stage III or IV melanoma, with a ORR of 73% (8/11) and pCR of 45% (5/11), however, demonstrated higher toxicity (PMID: 30297909; NCT02519322). 30297909
Unknown unknown renal cell carcinoma not applicable Nivolumab + Ipilimumab FDA approved Actionable In a Phase III trial that supported FDA approval, the combination of Opdivo (nivolumab) and Yervoy (ipilimumab) resulted in an 18-mo overall survival (OS) rate of 75% vs. 60% (HR=0.63, p<0.001), and median OS that was not reached vs. 25.9 months with Sutent (sunitinib), and resulted in an objective response rate of 42%, with 40 (9%) complete responses (CR), vs. ORR of 27%, with 5 CR (1%) with Sutent (sunitinib) in patients with intermediate or poor risk renal cell carcinoma (PMID: 29562145; NCT02231749). 29562145
Unknown unknown renal cell carcinoma not applicable Nivolumab + Ipilimumab Phase I Actionable In a Phase I trial, the combination of Opdivo (nivolumab) and Yervoy (ipilimumab) demonstrated safety using 2 different dosing regimens (N3I1=nivolumab 3mg/kg+ipilumumab 1mg/kg; N1I3=nivolumab 1mg/kg+ipilumumab 3mg/kg) in patients with metastatic renal cell carcinoma, and resulted in an objective response rate of 40.4% (19/47) in both N3I1 and N1I3 arms and a 2-year overall survival of 67% in the N3I1 arm and 70% in the N1I3 arm (PMID: 28678668; NCT01472081). 28678668
Clinical Trial Phase Therapies Title Recruitment Status
NCT03377023 Phase Ib/II Nivolumab + Ipilimumab Ipilimumab + Nintedanib + Nivolumab Phase I/II Study of Nivolumab and Ipilimumab Combined With Nintedanib in Non Small Cell Lung Cancer Recruiting
NCT02320058 Phase II Nivolumab + Ipilimumab A Multi-Center Phase 2 Open-Label Study to Evaluate Safety and Efficacy in Subjects With Melanoma Metastatic to the Brain Treated With Nivolumab in Combination With Ipilimumab Followed by Nivolumab Monotherapy (CheckMate 204) Active, not recruiting
NCT02408861 Phase I Nivolumab + Ipilimumab Nivolumab and Ipilimumab in Treating Patients With Advanced HIV Associated Solid Tumors Recruiting
NCT03117309 Phase II Nivolumab + Ipilimumab Nivolumab Study of Front Line Therapy With Nivolumab and Salvage Nivolumab + Ipilimumab in Patients With Advanced Renal Cell Carcinoma Recruiting
NCT02741570 Phase III Carboplatin + Cetuximab + Cisplatin + Fluorouracil Nivolumab + Ipilimumab Study of Nivolumab in Combination With Ipilimumab Compared to the Standard of Care (Extreme Study Regimen) as First Line Treatment in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Active, not recruiting
NCT03029780 Phase II Nivolumab + Ipilimumab An Investigational Immuno-Therapy Safety and Efficacy Study of Multiple Administration Regimens for Nivolumab Plus Ipilimumab in Subjects With Renal Cell Carcinoma Active, not recruiting
NCT02186249 Phase III Nivolumab + Ipilimumab Expanded Access Program With Nivolumab (BMS-936558) in Combination With Ipilimumab (Yervoy®) in Anti-CTLA-4 Treatment-Naïve Subjects With Unresectable or Metastatic Melanoma (CheckMate 218) No longer available
NCT02017717 Phase III Nivolumab Bevacizumab Nivolumab + Ipilimumab A Randomized Study of Nivolumab Versus Bevacizumab and a Safety Study of Nivolumab in Adult Subjects With Recurrent Glioblastoma (GBM) (CheckMate 143) Active, not recruiting
NCT03223155 Phase I Nivolumab + Ipilimumab Evaluate Concurrent Or Sequential Ipilimumab, Nivolumab, and Stereotactic Body Radiotherapy in Patients With Stage IV Non-Small Cell Lung Cancer Recruiting
NCT03126461 Phase II Nivolumab + Ipilimumab SAbR Plus Ipilimumab Plus Nivolumab in Metastatic Melanoma Patients Withdrawn
NCT03172624 Phase II Nivolumab + Ipilimumab Study of Nivolumab Plus Ipilimumab in Patients With Salivary Gland Cancer Recruiting
NCT03575793 Phase Ib/II Ipilimumab + Nivolumab + Plinabulin Nivolumab + Ipilimumab A Phase I/II Study of Nivolumab, Ipilimumab and Plinabulin in Patients With Recurrent Small Cell Lung Cancer Recruiting
NCT02834013 Phase 0 Nivolumab + Ipilimumab Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting
NCT03101566 Phase II Cisplatin + Gemcitabine + Nivolumab Nivolumab + Ipilimumab Study of Nivolumab in Combination With Gemcitabine/Cisplatin or Ipilimumab for Patients With Advanced Unresectable Biliary Tract Cancer Recruiting
NCT03668119 Phase II Nivolumab + Ipilimumab Nivolumab A Study of Nivolumab Combined With Ipilimumab and Nivolumab Alone in Patients With Advanced or Metastatic Solid Tumors of High Tumor Mutational Burden (TMB-H) Recruiting
NCT03333616 Phase II Nivolumab + Ipilimumab Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary Tumors Recruiting
NCT03285321 Phase II Nivolumab + Ipilimumab Nivolumab Unresectable Stage IIIA/IIIB Non-small Cell Lung Cancer (NSCLC) Recruiting
NCT02935634 Phase II Nivolumab + Relatlimab Nivolumab + Ipilimumab A Study to Test Combination Treatments in Patients With Advanced Gastric Cancer (FRACTION-GC) Recruiting
NCT02224781 Phase III Nivolumab + Ipilimumab Trametinib + Dabrafenib Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma Recruiting
NCT03420521 Phase II Nivolumab + Ipilimumab Nivolumab With Ipilimumab in Subjects With Neuroendocrine Tumors Recruiting
NCT03570619 Phase II Nivolumab + Ipilimumab Immunotherapy iImmunotherapy in Patients With Metastatic Cancers and CDK12 Mutations (IMPACT) Recruiting
NCT02970981 Phase II Nivolumab + Ipilimumab Study of Combination of Ipilimumab and Nivolumab in Patients With Melanoma Active, not recruiting
NCT03342417 Phase II Nivolumab + Ipilimumab Combination of Nivolumab and Ipilimumab in Breast, Ovarian and Gastric Cancer Patients Recruiting
NCT02846376 Phase I Ipilimumab Nivolumab + Ipilimumab Nivolumab Single Agent and Combined Inhibition After Allogeneic Stem Cell Transplant (CPIT-002) Recruiting
NCT02880020 Phase II Nivolumab Nivolumab + Ipilimumab Nivolumab With or Without Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumor That Is Metastatic or Cannot Be Removed by Surgery Recruiting
NCT03203473 Phase II Nivolumab Nivolumab + Ipilimumab Study of Optimized Management of Nivolumab Based on Response in Patients With Advanced RCC (OMNIVORE Study) Recruiting
NCT03829111 Phase I Nivolumab + Ipilimumab CBM588 + Ipilimumab + Nivolumab CBM588, Nivolumab, and Ipilimumab in Treating Patients With Stage IV or Advanced Kidney Cancer Not yet recruiting
NCT03521830 Phase II Nivolumab Nivolumab + Ipilimumab Nivolumab Alone or Plus Ipilimumab for Patients With Locally-Advanced Unresectable or Metastatic Basal Cell Carcinoma Recruiting
NCT03355976 Phase II Nivolumab + Ipilimumab Nivolumab BrUOG 354 Nivolumab +/- Ipilimumab for Ovarian and Extra-renal Clear Cell Carcinomas Recruiting
NCT03001882 Phase II Nivolumab + Ipilimumab An Exploratory Study of the Effects of Nivolumab Combined With Ipilimumab in Patients With Treatment-Naive Stage IV or Recurrent Non-Small Cell Lung Cancer (NSCLC) Recruiting
NCT02899299 Phase III Carboplatin + Cisplatin + Pemetrexed Nivolumab + Ipilimumab Study of Nivolumab Combined With Ipilimumab Versus Pemetrexed and Cisplatin or Carboplatin as First Line Therapy in Unresectable Pleural Mesothelioma Patients (CheckMate743) Active, not recruiting
NCT03065179 Phase II Nivolumab + Ipilimumab Trial of SBRT in Combination With Nivolumab/Ipilimumab in RCC / Kidney Cancer Patients Recruiting
NCT02864251 Phase III Nivolumab Nivolumab + Ipilimumab Carboplatin + Cisplatin + Pemetrexed A Study of Nivolumab + Chemotherapy or Nivolumab + Ipilimumab Versus Chemotherapy in Patients With EGFR Mutation, T790M Negative NSCLC Who Have Failed 1L EGFR TKI Therapy (CheckMate722) Recruiting
NCT02978443 Phase II Nivolumab + Ipilimumab A Biomarker Study in Advanced Mucosal or Acral Lentiginous Melanoma Receiving Nivolumab in Combination With Ipilimumab Recruiting
NCT03162731 Phase I Nivolumab + Ipilimumab Nivolumab, Ipilimumab, and Radiation Therapy in Treating Patients With Stage IVA-B Head and Neck Cancer Recruiting
NCT03776487 Phase Ib/II Fluorouracil + Oxaliplatin Nivolumab Nivolumab + Ipilimumab Fluorouacil + Ipilimumab + Nivolumab Nivolumab, Ipilimumab and Chemoradiation in Treating Patients With Resectable Gastric Cancer Recruiting
NCT03425331 Phase II Nivolumab + Ipilimumab Biomarkers of Response to Ipilimumab and Nivolumab in First-line NSCLC Recruiting
NCT03305445 Phase Ib/II Nivolumab + Ipilimumab Nivolumab/Ipilimumab-Primed Immunotransplant for DLBCL Recruiting
NCT02939300 Phase II Nivolumab + Ipilimumab Ipilimumab and Nivolumab in Leptomeningeal Metastases From Melanoma Recruiting
NCT03130959 Phase II Nivolumab + Ipilimumab Nivolumab An Investigational Immuno-therapy Study of Nivolumab Monotherapy and Nivolumab in Combination With Ipilimumab in Pediatric Patients With High Grade Primary CNS Malignancies (CheckMate 908) Recruiting
NCT03719131 Phase II Nivolumab + Ipilimumab Ipilimumab + Nivolumab + Rituximab Rituximab and Hyaluronidase Human in Patients With Advanced Melanoma Undergoing Nivolumab and Ipilimumab Therapy Not yet recruiting
NCT03597282 Phase I Nivolumab + Ipilimumab APX005M + Nivolumab Ipilimumab + NEO-PV-01 + Nivolumab + poly ICLC APX005M + NEO-PV-01 + Nivolumab + poly ICLC Nivolumab + poly ICLC NEO-PV-01 + Nivolumab + poly ICLC A Personal Cancer Vaccine (NEO-PV-01) and APX005M or Ipilimumab With Nivolumab in Patients With Advanced Melanoma Recruiting
NCT03508570 Phase I Nivolumab Nivolumab + Ipilimumab Nivolumab With or Without Ipilimumab in Treating Participants With Recurrent or High Grade Gynecologic Cancer With Metastatic Peritoneal Carcinomatosis Recruiting
NCT03799445 Phase II Nivolumab + Ipilimumab Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma Not yet recruiting
NCT02833233 Phase I Nivolumab + Ipilimumab A Study of Pre-Operative Treatment With Cryoablation and Immune Therapy in Early Stage Breast Cancer Active, not recruiting
NCT03297606 Phase II Bosutinib Palbociclib Vismodegib Nivolumab + Ipilimumab Vemurafenib + Cobimetinib Temsirolimus Olaparib Erlotinib Crizotinib Sunitinib Afatinib Dasatinib Pertuzumab + Trastuzumab Axitinib Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR) (CAPTUR) Recruiting
NCT03670056 Phase II Nivolumab + Ipilimumab A Pilot Study of Combination Immunotherapy With Ipilimumab and Nivolumab in Patients With Recurrent Extensive Stage Small Cell Lung Cancer (SCLC) Who Have Previously Received Platinum-based Chemotherapy Not yet recruiting
NCT03033576 Phase II Ipilimumab Nivolumab + Ipilimumab Ipilimumab With or Without Nivolumab in Treating Patients With Melanoma That is Stage IV or Stage III and Cannot Be Removed by Surgery Recruiting
NCT03043599 Phase Ib/II Nivolumab + Ipilimumab Ipilimumab + Nivolumab w/Thoracic Radiotherapy for Extensive-Stage Small Cell Lung Cancer Active, not recruiting
NCT02453620 Phase I Entinostat Nivolumab + Ipilimumab Entinostat, Nivolumab, and Ipilimumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Locally Advanced or Metastatic HER2-Negative Breast Cancer Recruiting
NCT03520491 Phase II Nivolumab + Ipilimumab Nivolumab A Study to Test the Safety of Immunotherapy With Nivolumab Alone or With Ipilimumab Before Surgery for Bladder Cancer Patients Who Are Not Suitable for Chemotherapy Recruiting
NCT02599402 Phase III Nivolumab + Ipilimumab Nivolumab Nivolumab Combined With Ipilimumab Followed by Nivolumab Monotherapy as First-Line Treatment for Patients With Advanced Melanoma Active, not recruiting
NCT03138512 Phase III Nivolumab + Ipilimumab A Study Comparing the Combination of Nivolumab and Ipilimumab Versus Placebo in Participants With Localized Renal Cell Carcinoma (CheckMate 914) Recruiting
NCT03528408 Phase II Nivolumab + Ipilimumab Study of Adjuvant Ipilimumab and Nivolumab in Subjects With High-risk Ocular Melanoma Recruiting
NCT03377361 Phase Ib/II Nivolumab + Ipilimumab Ipilimumab + Nivolumab + Trametinib An Investigational Immuno-therapy Study Of Nivolumab In Combination With Trametinib With Or Without Ipilimumab In Patients With Previously Treated Cancer of the Colon or Rectum That Has Spread Recruiting
NCT03651271 Phase II Nivolumab + Ipilimumab Nivolumab Treatment With Nivolumab and Ipilimumab or Nivolumab Alone According to the Percentage of Tumoral CD8 Cells in Advanced Metastatic Cancer Recruiting
NCT03220009 Phase II Nivolumab + Ipilimumab Nivolumab or Expectant Observation Following Ipilimumab, Nivolumab, and Surgery in Treating Patients With High Risk Localized, Locoregionally Advanced, or Recurrent Mucosal Melanoma Withdrawn
NCT03146650 Phase II Nivolumab + Ipilimumab Nivolumab and Ipilimumab in Treating Patients With Metastatic Recurrent Major or Minor Salivary Gland Cancer Recruiting
NCT03104439 Phase II Nivolumab + Ipilimumab Nivolumab and Ipilimumab and Radiation Therapy in MSS and MSI High Colorectal and Pancreatic Cancer Recruiting
NCT02656706 Phase II Nivolumab + Ipilimumab BrUOG 324: Adjuvant Nivolumab and Low Dose Ipilimumab for Stage III and Resected Stage IV Melanoma: A Phase II Brown University Oncology Research Group Trial Recruiting
NCT03646617 Phase II Nivolumab + Ipilimumab Ipilumumab and Nivolumab With or Without Hypofractionated Radiotherapy in Patients With Metastatic Melanoma Recruiting
NCT02736123 Phase Ib/II Nivolumab Nivolumab + Ipilimumab Neoadjuvant Combination Biotherapy With Ipilimumab and Nivolumab or Nivolumab Alone Withdrawn
NCT02231749 Phase III Nivolumab + Ipilimumab Sunitinib Nivolumab Combined With Ipilimumab Versus Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma (CheckMate 214) Active, not recruiting
NCT03461952 Phase II Nivolumab Nivolumab + Ipilimumab Nivolumab Ipilimumab in Patients With hyperMutated Cancers Detected in Blood (NIMBLe) (NIMBLe) Recruiting
NCT03256136 Phase II Carboplatin + Nivolumab + Pemetrexed Nivolumab + Ipilimumab A Phase II Study of Nivolumab in Combination With Carboplatin and Pemetrexed, or Nivolumab in Combination With Ipilimumab, in Patients With Advanced, EGFR-mutant or ALK-rearranged, Non-Small Cell Lung Cancer Recruiting
NCT02823574 Phase II Nivolumab Nivolumab + Ipilimumab Study of Nivolumab in Combination With Ipilimumab Versus Nivolumab in Combination With Ipilimumab Placebo in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Active, not recruiting
NCT02714218 Phase III Nivolumab + Ipilimumab A Study of Two Different Dose Combinations of Nivolumab in Combination With Ipilimumab in Subjects With Previously Untreated, Unresectable or Metastatic Melanoma Active, not recruiting
NCT03215706 Phase III Carboplatin + Cisplatin + Paclitaxel + Pemetrexed Nivolumab + Ipilimumab A Study of Nivolumab and Ipilimumab Combined With Chemotherapy Compared to Chemotherapy by Itself as the First Treatment Given for Stage IV Non-Small Cell Lung Cancer (NSCLC) (CheckMate 9LA) Recruiting
NCT03203304 Phase I Nivolumab Nivolumab + Ipilimumab Study of Stereotactic Body Radiotherapy (SBRT) Followed by Nivolumab or Ipilimumab With Nivolumab in Unresectable Hepatocellular Carcinoma Recruiting
NCT03789110 Phase II Nivolumab + Ipilimumab NIMBUS: A Phase II Study of Nivolumab Plus Ipilimumab in Metastatic Hypermutated HER2-negative Breast Cancer Not yet recruiting
NCT02982954 Phase III Nivolumab + Ipilimumab A Study to Evaluate the Safety of Nivolumab and Ipilimumab in Subjects With Previously Untreated Advanced or Metastatic Renal Cell Cancer (CHECKMATE 920) Active, not recruiting
NCT03143153 Phase III Nivolumab + Ipilimumab Cisplatin + Fluorouracil Nivolumab + Cisplatin + Fluorouacil A Study to Evaluate Efficacy in Subjects With Esophageal Cancer Treated With Nivolumab and Ipilimumab or Nivolumab Combined With Fluorouracil Plus Cisplatin Versus Fluorouracil Plus Cisplatin (CheckMate 648) Recruiting
NCT03391869 Phase III Nivolumab + Ipilimumab Trial of Local Consolidation Therapy (LCT) After Nivolumab and Ipilimumab (LONESTAR) Recruiting
NCT03158129 Phase II Nivolumab Nivolumab + Ipilimumab Study Of Induction Checkpoint Blockade For Untreated Stage I-IIIA Non-Small Cell Lung Cancers Amenable For Surgical Resection Recruiting
NCT02785952 Phase III Nivolumab Nivolumab + Ipilimumab Lung-MAP: Nivolumab With or Without Ipilimumab as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and No Matching Biomarkers Recruiting
NCT02985957 Phase II Nivolumab + Ipilimumab A Study to Evaluate Preliminary Safety and Efficacy of Nivolumab Plus Ipilimumab in Men With Metastatic Castration-Resistant Prostate Cancer Active, not recruiting
NCT03222076 Phase II Nivolumab + Ipilimumab Nivolumab Study Evaluating Nivolumab (Anti-PD-1 Antibody) Alone Versus Nivolumab Plus Ipilimumab (Anti-CTLA-4 Antibody) in Patients With Resectable and Potentially Resectable Hepatocellular Carcinoma (HCC) (CA209-956) Recruiting
NCT03463408 Phase I Nivolumab + Ipilimumab Immunotherapy + Radiation in Resectable Soft Tissue Sarcoma Recruiting
NCT03335540 Phase I BMS-986205 + Nivolumab Nivolumab + Relatlimab Cabiralizumab + Nivolumab Lirilumab + Nivolumab BMS-986156 + Nivolumab Nivolumab + Ipilimumab Nivolumab An Adaptive Study to Match Patients With Solid Tumors to Various Immunotherapy Combinations Based Upon a Broad Biomarker Assessment Recruiting
NCT02659059 Phase II Nivolumab + Ipilimumab Nivolumab Plus Ipilimumab to Treat First Line Stage IV Non-Small Cell Lung Cancer (CheckMate568) Active, not recruiting
NCT03036098 Phase III Gemcitabine + Cisplatin Nivolumab + Ipilimumab Carboplatin + Gemcitabine Study of Nivolumab in Combination With Ipilimumab Compared to the Standard of Care Chemotherapy in Treatment of Patients With Untreated Inoperable or Metastatic Urothelial Cancer Recruiting
NCT03274258 Phase II Nivolumab + Ipilimumab Nivolumab Plus Ipilimumab in Patients With Renal Medullary Carcinoma Recruiting
NCT02210117 Phase II Nivolumab Bevacizumab + Nivolumab Nivolumab + Ipilimumab Nivolumab vs Nivolumab + Bevacizumab vs Nivolumab + Ipilimumab in Metastatic Renal Cell Carcinoma (mRCC) Active, not recruiting
NCT03749460 Phase Ib/II Nivolumab + Ipilimumab Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers Recruiting
NCT02601014 Phase II Nivolumab + Ipilimumab Biomarker-Driven Therapy With Nivolumab and Ipilimumab in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Expressing AR-V7 Recruiting
NCT03241186 Phase II Nivolumab + Ipilimumab Ipilimumab and Nivolumab as Adjuvant Treatment of Mucosal Melanoma Recruiting
NCT02996110 Phase II Nivolumab + Relatlimab Nivolumab + Ipilimumab A Study to Test Combination Treatments in People With Advanced Renal Cell Carcinoma (FRACTION-RCC) Recruiting
NCT02304458 Phase Ib/II Nivolumab + Ipilimumab Nivolumab With or Without Ipilimumab in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Sarcomas Recruiting
NCT03600155 Phase I Nivolumab Ipilimumab Nivolumab + Ipilimumab Nivolumab and Ipilimumab After Donor Stem Cell Transplant in Treating Participants With High Risk Refractory or Relapsed Acute Myeloid Leukemia Recruiting
NCT02681302 Phase Ib/II Nivolumab + Ipilimumab Study of Combined Check Point Inhibition After Autologous Hematopoietic Stem Cell Transplantation in Patients at High Risk for Post-transplant Recurrence (CPIT001) Recruiting
NCT03367715 Phase II Nivolumab + Ipilimumab Nivolumab, Ipilimumab, and Short-course Radiotherapy in Adults With Newly Diagnosed, MGMT Unmethylated Glioblastoma Recruiting
NCT03071406 Phase II Nivolumab + Ipilimumab Randomized Study of Nivolumab+Ipilimumab+/- SBRT for Metastatic Merkel Cell Carcinoma Recruiting
NCT02998528 Phase III Nivolumab + Ipilimumab Cisplatin + Vinorelbine + Gemcitabine + Docetaxel + Pemetrexed + Carboplatin A Neoadjuvant Study of Nivolumab and Ipilimumab Compared to Chemotherapy Doublet in Early Stage Non-Small Cell Lung Cancer (NSCLC) (CheckMate 816) Recruiting
NCT03604991 Phase II Paclitaxel + Carboplatin Nivolumab Nivolumab + Carboplatin + Paclitaxel Nivolumab + Ipilimumab Carboplatin, Paclitaxel and Radiation Therapy With or Without Nivolumab and Ipilimumab in Treating Participants With Esophageal and Gastroesophageal Junction Adenocarcinoma Recruiting
NCT03048136 Phase III Nivolumab + Ipilimumab A Safety Study of Nivolumab in Combination With Ipilimumab in Participants With Advanced Non-small Cell Lung Cancer (CheckMate 955) Withdrawn
NCT03430791 Phase II Nivolumab + Ipilimumab Nivolumab Trial of Combination TTF(Optune), Nivolumab Plus/Minus Ipilimumab for Bevacizumab-naïve, Recurrent Glioblastoma Recruiting
NCT02869789 Phase III Nivolumab + Ipilimumab A Safety Study of Nivolumab in Combination With Ipilimumab to Treat Advanced Cancers Recruiting
NCT03262779 Phase II Nivolumab + Ipilimumab Ipilimumab and Nivolumab in Patients With Anti-PD-1-axis Therapy-resistant Advanced Non-small Cell Lung Cancer. Recruiting
NCT02659540 Phase I Nivolumab + Ipilimumab A Pilot Study to Evaluate the Safety and Efficacy of Combination Checkpoint Blockade Plus External Beam Radiotherapy in Subjects With Stage IV Melanoma Active, not recruiting
NCT03546686 Phase II Nivolumab + Ipilimumab Peri-Operative Ipilimumab+Nivolumab and Cryoablation Versus Standard Care in Women With Triple-negative Breast Cancer Recruiting
NCT03724968 Phase II Nivolumab + Relatlimab Nivolumab + Ipilimumab Nivolumab Plus Relatlimab or Ipilimumab in Metastatic Melanoma Stratified by MHC-II Expression Recruiting
NCT02919683 Phase II Nivolumab Nivolumab + Ipilimumab Window Study of Nivolumab With or Without Ipilimumab in Squamous Cell Carcinoma of the Oral Cavity Recruiting
NCT03798639 Phase I Nivolumab + Ipilimumab Nivolumab Nivolumab and Radiation Therapy or Ipilimumab as Adjuvant Therapy in Treating Patients With Merkel Cell Cancer Recruiting
NCT03149159 Phase II Nivolumab + Ipilimumab Investigator-Initiated Trial of Combined Ipilimumab, Nivolumab and Stereotactic Radiation in Patients With Metastatic Clear-Cell RCC (ccRCC) Who Have Failed Treatment With Single-Agent Nivolumab Withdrawn
NCT02892734 Phase II Nivolumab + Ipilimumab Ipilimumab and Nivolumab in Treating Patients With Recurrent Stage IV HER2 Negative Inflammatory Breast Cancer Active, not recruiting
NCT01822509 Phase I Nivolumab + Ipilimumab Ipilimumab or Nivolumab in Treating Patients With Relapsed Hematologic Malignancies After Donor Stem Cell Transplant Active, not recruiting
NCT03246958 Phase II Nivolumab + Ipilimumab Nivolumab Plus Ipilimumab in Thyroid Cancer Recruiting
NCT03307616 Phase II Nivolumab + Ipilimumab Nivolumab Study of Neoadjuvant Checkpoint Blockade in Patients With Surgically Resectable Undifferentiated Pleomorphic Sarcoma and Dedifferentiated Liposarcoma Recruiting
NCT03693846 Phase II Nivolumab + Ipilimumab Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors Not yet recruiting
NCT03425292 Phase I Temozolomide Nivolumab + Ipilimumab Nivolumab A Longitudinal Assessment of Tumor Evolution in Patients With Brain Cancer Recruiting
NCT03068455 Phase III Nivolumab Ipilimumab Nivolumab + Ipilimumab A Study of Nivolumab in Combination With Ipilimumab Compared to Nivolumab or Ipilimumab Alone in Treatment of Patients After Complete Resection of Stage IIIb/c/d or Stage IV Melanoma (CheckMate 915) Active, not recruiting
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