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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
MLH1 negative Pembrolizumab ampulla of Vater adenocarcinoma sensitive detail...
MSH6 negative Pembrolizumab ampulla of Vater adenocarcinoma sensitive detail...
MLH1 negative Dostarlimab-gxly ampulla of Vater adenocarcinoma sensitive detail...
MSH6 negative Dostarlimab-gxly ampulla of Vater adenocarcinoma sensitive detail...
MSH6 negative Ipilimumab + Nivolumab ampulla of Vater adenocarcinoma sensitive detail...
MLH1 negative Ipilimumab + Nivolumab ampulla of Vater adenocarcinoma sensitive detail...
BRAF V600E Dabrafenib + Trametinib ampulla of Vater adenocarcinoma sensitive detail...
RET fusion Selpercatinib ampulla of Vater adenocarcinoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01202409 Phase II Panitumumab CAPOX in KRAS Wild-Type Advanced Adenocarcinoma of the Small Bowel or Ampulla of Vater Completed USA 0
NCT01208103 Phase II Bevacizumab + Capecitabine + Oxaliplatin Bevacizumab With Capecitabine and Oxaliplatin in Advanced Adenocarcinoma of the Small Bowel or Ampulla of Vater Completed USA 0
NCT02711553 Phase II Ramucirumab Merestinib Cisplatin + Gemcitabine A Study of Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer Active, not recruiting USA | GBR | FRA | ESP | DEU | BEL | AUT | AUS 10
NCT03801915 Phase II MVT-5873 Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers Completed USA 0
NCT04163900 Phase III Cisplatin + NUC-1031 Cisplatin + Gemcitabine Comparing NUC-1031 Plus Cisplatin to Gemcitabine Plus Cisplatin in Patients With Advanced Biliary Tract Cancer (NuTide:121) Terminated USA | ITA | GBR | FRA | ESP | DEU | CAN | AUS 7
NCT05512377 Phase II BI 907828 Brightline-2: A Study to Test Whether Brigimadlin (BI 907828) Helps People With Cancer in the Biliary Tract, Pancreas, Lung or Bladder Recruiting USA | GBR | FRA | ESP | DEU | BEL | AUT | AUS 6
NCT06333314 Phase II Dostarlimab-gxly Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin Doxorubicin Gemcitabine Gemcitabine + Nab-paclitaxel Doxorubicin + Trabectedin Fluorouracil + Leucovorin + Oxaliplatin Cisplatin + Etoposide Cisplatin + Gemcitabine Cisplatin + Doxorubicin + Etoposide Capecitabine + Oxaliplatin Doxorubicin + Ifosfamide Carboplatin + Etoposide Carboplatin + Paclitaxel Docetaxel + Fluorouracil + Leucovorin + Oxaliplatin Mitotane Dostarlimab for Locally Advanced or Metastatic Cancer (Non-colorectal/Non-endometrial) With Tumor dMMR/MSI (Pan-MSI-ACSE) Not yet recruiting FRA 0