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Therapy Name | Balstilimab + Botensilimab |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Balstilimab | AGEN-2034|AGEN2034 | Immune Checkpoint Inhibitor 146 PD-L1/PD-1 antibody 112 | Balstilimab (AGEN2034) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 ligand (CD274), potentially resulting in enhanced anti-tumor immune response (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 3086-3086). | |
Botensilimab | AGEN1181|AGEN 1181|AGEN-1181 | CTLA4 Antibody 28 Immune Checkpoint Inhibitor 146 | Botensilimab (AGEN1181) is an antibody that targets CTLA4, potentially resulting in increased anti-tumor immune response (Journal for ImmunoTherapy of Cancer 2021;9). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT05928806 | Phase II | Balstilimab + Botensilimab Ipilimumab + Nivolumab | Advanced Renal Cell Cancer Combination ImmunoThErapy Clinical Trial (ARCITECT) | Recruiting | USA | 0 |
NCT05571293 | Phase II | Balstilimab + Botensilimab | Combination Immunotherapy in Colorectal Cancer (NEST-1) | Recruiting | USA | 0 |
NCT05608044 | Phase II | Balstilimab + Botensilimab Botensilimab | A Study of Botensilimab and Balstilimab for the Treatment of Colorectal Cancer | Recruiting | USA | ITA | FRA | ESP | BEL | 2 |