Fluorouracil
|
Adrucil |
5-FU |
Chemotherapy - Antimetabolite
10
|
Adrucil (fluorouracil) is an antimetabolite chemotherapeutic agent, which interferes with DNA and RNA synthesis thereby preventing cancer cell growth (NCI Drug Dictionary). Fluorouracil is FDA approved for colorectal, breast, stomach, and pancreatic cancer (FDA.gov). |
Leucovorin
|
Wellcovorin |
Calcium folinate|Calcium citrovorum factor|folinic acid |
Chemotherapy - Antimetabolite
10
|
Wellcovorin (leucovorin) is a metabolite of folate that enhances the efficacy of fluoruracil (NCI Drug Dictionary). |
Nivolumab
|
Opdivo |
MDX-1106|BMS-936558 |
Immune Checkpoint Inhibitor
99
PD-L1/PD-1 antibody
48
|
Opdivo (nivolumab) is an antibody that targets PD-1 (PDCD1), which results in increased T-cell activation and enhanced anti-tumor immune response (NCI Drug Dictionary). Opdivo (nivolumab) is FDA approved for the treatment of metastatic melanoma, squamous NSCLC, metastatic small cell lung cancer, renal cell carcinoma, head and neck squamous cell carcinoma, urothelial carcinoma, Hodgkin's lymphoma, hepatocellular carcinoma, and for dMMR or MSI-H colorectal cancer as a single agent or in combination with Yervoy (ipilimumab) (FDA.gov). |
Oxaliplatin
|
Eloxatin |
Diaminocyclohexane Oxalatoplatinum |
Chemotherapy - Platinum
6
|
Eloxatin (oxaliplatin) is comprised of a platinum complex, which causes DNA-platinum cross-links, inhibition of DNA replication and transcription, and cell toxicity (NCI Drug Dictionary). Eloxatin (oxaliplatin) is FDA approved for colorectal cancer (FDA.gov). |