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Therapy Name Balstilimab
Synonyms
Therapy Description

Balstilimab (AGEN2034) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 ligand (CD274), potentially resulting in enhanced anti-tumor immune response (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 3086-3086).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Balstilimab AGEN-2034|AGEN2034 Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 117 Balstilimab (AGEN2034) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 ligand (CD274), potentially resulting in enhanced anti-tumor immune response (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 3086-3086).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04943627 Phase III Topotecan Balstilimab Gemcitabine Irinotecan Pemetrexed Disodium Vinorelbine Balstilimab in Patients With Recurrent Cervical Cancer. Withdrawn USA 1
NCT04607200 Phase II Balstilimab + Zalifrelimab Balstilimab AGEN2034 & AGEN1884 in Patients With Recurrent, Inoperable Angiosarcoma Withdrawn 0
NCT03104699 Phase Ib/II Balstilimab Phase 1 / 2 Study of AGEN2034 in Advanced Tumors and Cervical Cancer Completed USA | FRA | ESP | BEL | AUS 4
NCT03894215 Phase II Balstilimab Balstilimab + Zalifrelimab Phase 2 Study of Anti-PD-1 Independently or in Combination With Anti-CTLA-4 in Second-Line Cervical Cancer Active, not recruiting USA 6
NCT05363709 Phase II Balstilimab A Phase 2 Study To Assess The Effect Of BALSTILIMAB (AGEN2034) On Viral Clearance In HPV-Positive Oropharyngeal Cancer Patients With Persistent HPV Detection In The Oral Rinse And/Or Plasma cfDNA After Definitive Therapy Recruiting USA 0
NCT06279130 Phase II Balstilimab Balstilimab + Botensilimab Pan-tumor Neoadjuvant Basket Study of Immune Check-point Inhibition and Novel Immuno-oncology Combinations (NEOASIS) Recruiting NLD 0


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