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Drug Name SGT-53
Trade Name
Synonyms transferrin receptor-targeted liposomal p53 cDNA|Synerlip p53
Drug Descriptions

SGT-53 is a cationic liposomal complex that is linked to an antibody targeting the transferrin receptor (Tff) and contains wild-type Tp53 plasmid, thereby delivering wild-type Tp53 to tumor cells expressing Tff and potentially restoring wild-type Tp53 activity (PMID: 23470564, PMID: 27357628, PMID: 31241175)

DrugClasses p53 Gene Therapy 4


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Irinotecan + SGT-53 + Temozolomide Bevacizumab Irinotecan SGT-53 Temozolomide 0 1
Cyclophosphamide + SGT-53 + Topotecan Cyclophosphamide SGT-53 Topotecan 0 1
Docetaxel + SGT-53 Docetaxel SGT-53 1 0
SGT-53 SGT-53 0 2

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