Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name SGT-53
Trade Name
Synonyms transferrin receptor-targeted liposomal p53 cDNA|Synerlip p53
Drug Descriptions

SGT-53 is a cationic liposomal complex that is linked to an antibody targeting the transferrin receptor (Tff) and contains wild-type Tp53 plasmid, thereby delivering wild-type Tp53 to tumor cells expressing Tff and potentially restoring wild-type Tp53 activity (PMID: 23470564, PMID: 27357628, PMID: 31241175)

DrugClasses p53 Gene Therapy 4
CAS Registry Number NA
NCIT ID C29474


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Irinotecan + SGT-53 + Temozolomide Bevacizumab Irinotecan SGT-53 Temozolomide 0 1
Carboplatin + Pembrolizumab + SGT-53 Carboplatin Pembrolizumab SGT-53 0 1
Cyclophosphamide + SGT-53 + Topotecan Cyclophosphamide SGT-53 Topotecan 0 1
Docetaxel + SGT-53 Docetaxel SGT-53 0 0
SGT-53 SGT-53 0 2

Additional content available in CKB BOOST