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Drug Name GSK2830371
Trade Name
Synonyms GSK-2830371
Drug Descriptions

GSK2830371 is an allosteric, small molecule inhibitor of PPM1D, which results in increased phosphorylation Ppm1d substrates and may result in tumor growth inhibition (PMID: 24390428, PMID: 31136458).

DrugClasses PPM1D Inhibitor 3
CAS Registry Number 1404456-53-6
NCIT ID NA

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + GSK2830371 Carboplatin GSK2830371 1 0
Cytarabine + GSK2830371 Cytarabine GSK2830371 0 0
Doxorubicin + GSK2830371 Doxorubicin GSK2830371 1 0
GSK2830371 GSK2830371 2 0
GSK2830371 + Idasanutlin GSK2830371 Idasanutlin 0 0
GSK2830371 + Nutlin-3a GSK2830371 Nutlin-3a 0 0
GSK2830371 + Olaparib GSK2830371 Olaparib 0 0
GSK2830371 + Olaparib + Radiotherapy GSK2830371 Olaparib Radiotherapy 0 0


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