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Drug Name Nutlin-3a
Trade Name
Synonyms Nutlin|Nutlin-3
Drug Descriptions

Nutlin-3a is an MDM2 inhibitor which activates p53 and results in cancer cells undergoing apoptosis and cellular senescence. Nutlin-3 is a candidate for neoadjuvant therapy in cancers with a functional p53 (PMID: 18451145, PMID: 32653500).

DrugClasses MDM2 Inhibitor 19

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Nutlin-3a Carboplatin Nutlin-3a 0 0
CCT007093 + Nutlin-3a CCT007093 Nutlin-3a 0 0
Cisplatin + Nutlin-3a Cisplatin Nutlin-3a 0 0
CTX-1 + Nutlin-3a CTX-1 Nutlin-3a 0 0
Doxorubicin + Nutlin-3a Doxorubicin Nutlin-3a 0 0
Etoposide + Nutlin-3a Etoposide Nutlin-3a 0 0
GSK2830371 + Nutlin-3a GSK2830371 Nutlin-3a 0 0
Nutlin-3a Nutlin-3a 2 0
Nutlin-3a + Paclitaxel Nutlin-3a Paclitaxel 1 0
Nutlin-3a + RG7112 Nutlin-3a RG7112 0 0


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