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Drug Name RG7112
Trade Name
Synonyms RO5045337|RO-5045337
Drug Descriptions

RG7112 (RO5045337) binds to the p53-binding region of MDM2 and inhibits MDM2-p53 interaction, resulting in activation of p53 signaling, and decreased tumor cell growth (PMID: 24900694, PMID: 23400593, PMID: 31493899).

DrugClasses MDM2 Inhibitor 20
CAS Registry Number 939981-39-2
NCIT ID C91724


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Doxorubicin + RG7112 Doxorubicin RG7112 1 0
Nutlin-3a + RG7112 Nutlin-3a RG7112 0 0
RG7112 RG7112 1 0

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