Therapy Detail

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Therapy Name RG7112
Synonyms
Therapy Description

RG7112 (RO5045337) binds to the p53-binding region of MDM2 and inhibits MDM2-p53 interaction, resulting in activation of p53 signaling, and decreased tumor cell growth (PMID: 24900694, PMID: 23400593).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
RG7112 RO5045337|RO-5045337 MDM2 Inhibitor 19 RG7112 (RO5045337) binds to the p53-binding region of MDM2 and inhibits MDM2-p53 interaction, resulting in activation of p53 signaling, and decreased tumor cell growth (PMID: 24900694, PMID: 23400593, PMID: 31493899).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown acute myeloid leukemia not applicable RG7112 Phase I Actionable In a Phase I clinical trial, RG7112 demonstrated clinical activity in acute myeloid leukemia, with complete response in 7% (2/30), complete response with incomplete platelet recovery in 3% (1/30), partial response in 7% (2/30), and stable disease in 30% (9/30) of patients (PMID: 26459177). 26459177
Unknown unknown sarcoma not applicable RG7112 Phase I Actionable In a Phase I clinical trial, RG7112 demonstrated safety and preliminary efficacy, with evidence supporting p53 activation, in soft tissue sarcoma patients with MDM2 amplification (J Clin Oncol 30, 2012 (suppl; abstr e13600). detail...
Unknown unknown chronic leukemia not applicable RG7112 Phase I Actionable In a Phase I clinical trial, 5% (1/19) of chronic leukemia patients achieved partial response, and 79% (15/19) achieved stable disease following treatment with RG7112 (PMID: 26459177). 26459177

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status


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