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Drug Name Daratumumab and hyaluronidase-fihj
Trade Name Darzalex Faspro
Synonyms Daratumumab/rHuPH20|HuMax-CD38-rHuPH20|darzalex/rHuPH20
Drug Descriptions

Darzalex Faspro (Daratumumab and hyaluronidase-fihj) is a combination of the anti-CD38 antibody Daratumumab with hyaluronidase, which may be administered subcutaneously (PMID: 32213342). Darzalex Faspro (Daratumumab and hyaluronidase-fihj) is FDA approved as a monotherapy or in combination with lenalidomide and dexamethasone, or with pomalidomide and dexamethasone, or with bortezomib and dexamethasone, or with bortezomib, melphalan, and prednisone, or with Kyprolis (carfilzomib) and dexamethasone for patients with multiple myeloma, and in combination with bortezomib, cyclophosphamide and dexamethasone in patients with newly diagnosed light chain amyloidosis (FDA.gov).

DrugClasses CD38 Antibody 15
CAS Registry Number NA
NCIT ID C156401

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bortezomib + Daratumumab and hyaluronidase-fihj + Dexamethasone Bortezomib Daratumumab and hyaluronidase-fihj Dexamethasone 0 0
Bortezomib + Daratumumab and hyaluronidase-fihj + Dexamethasone + Lenalidomide Bortezomib Daratumumab and hyaluronidase-fihj Dexamethasone Lenalidomide 0 0
Bortezomib + Daratumumab and hyaluronidase-fihj + Dexamethasone + Panobinostat Bortezomib Daratumumab and hyaluronidase-fihj Dexamethasone Panobinostat 0 1
Bortezomib + Daratumumab and hyaluronidase-fihj + Melphalan + Prednisone Bortezomib Daratumumab and hyaluronidase-fihj Melphalan Prednisone 0 0
Carfilzomib + Daratumumab and hyaluronidase-fihj + Dexamethasone Carfilzomib Daratumumab and hyaluronidase-fihj Dexamethasone 0 0
Daratumumab and hyaluronidase-fihj Daratumumab and hyaluronidase-fihj 0 1
Daratumumab and hyaluronidase-fihj + Dexamethasone + Lenalidomide Daratumumab and hyaluronidase-fihj Dexamethasone Lenalidomide 0 0
Daratumumab and hyaluronidase-fihj + Dexamethasone + Pomalidomide Daratumumab and hyaluronidase-fihj Dexamethasone Pomalidomide 0 0
Daratumumab and hyaluronidase-fihj + Dexamethasone + Pomalidomide + Tazemetostat Daratumumab and hyaluronidase-fihj Dexamethasone Pomalidomide Tazemetostat 0 1
Daratumumab and hyaluronidase-fihj + FT538 Daratumumab and hyaluronidase-fihj FT538 0 1
Daratumumab and hyaluronidase-fihj + TAK-981 Daratumumab and hyaluronidase-fihj TAK-981 0 1


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