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|Therapy Name||Daratumumab and hyaluronidase-fihj + FT538|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Daratumumab and hyaluronidase-fihj||Darzalex Faspro||Daratumumab/rHuPH20|HuMax-CD38-rHuPH20|darzalex/rHuPH20||CD38 Antibody 14||Darzalex Faspro (Daratumumab and hyaluronidase-fihj) is a combination of the anti-CD38 antibody Daratumumab with hyaluronidase, which may be administered subcutaneously (PMID: 32213342). Darzalex Faspro (Daratumumab and hyaluronidase-fihj) is FDA approved as a monotherapy or in combination with lenalidomide and dexamethasone, or with pomalidomide and dexamethasone, or with bortezomib and dexamethasone, or with bortezomib, melphalan, and prednisone, or with Kyprolis (carfilzomib) and dexamethasone for patients with multiple myeloma, and in combination with bortezomib, cyclophosphamide and dexamethasone in patients with newly diagnosed light chain amyloidosis (FDA.gov).|
|FT538||FT-538|FT 538||FT538 consists of a preparation of natural killer cells derived from induced pluripotent stem cells engineered to lack CD38 and to express an IL-15 receptor alpha fusion protein and a non-cleavable form of CD16, which potentially induces enhanced antibody-dependent cellular cytotoxicity against tumor cells (Blood (2019) 134 (Supplement_1): 133).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04714372||Phase I||Cyclophosphamide + Fludarabine Daratumumab and hyaluronidase-fihj + FT538||FT538 in Combination With Daratumumab in AML Acute Myeloid Leukemia||Recruiting||USA||0|