Drug Detail


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Drug Name Tofacitinib
Trade Name Xeljanz
Synonyms Tasocitinib|CP-690550|CP-690,550
Drug Descriptions

Xeljanz (tofacitinib) is a pan-JAK inhibitor, which decreases downstream signaling and potentially leads to reduced tumor cell growth (PMID: 26300391, PMID: 21106989). Xeljanz (tofacitinib) is FDA approved for rheumatoid arthritis (FDA.gov).

DrugClasses JAK Inhibitor (Pan) - ATP competitive 3
CAS Registry Number 477600-75-2
NCIT ID C95800


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Dexamethasone + Tofacitinib Dexamethasone Tofacitinib 1 0
LMB-100 + Tofacitinib LMB-100 Tofacitinib 0 1
Midostaurin + Tofacitinib Midostaurin Tofacitinib 2 0
Tofacitinib Tofacitinib 20 1

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