Drug Detail


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Drug Name Revumenib
Trade Name
Synonyms SNDX5613|SNDX 5613|SNDX-5613
Drug Descriptions

Revumenib (SNDX-5613) inhibits the interaction between Menin and KMT2A (MLL), potentially resulting in antitumor activity and decreased proliferation of tumor cells with KMT2A (MLL) rearrangements or NPM1 mutations (PMID: 36922593, PMID: 36922589).

DrugClasses MEN1-KMT2A Inhibitor 7
CAS Registry Number 2169919-21-3
NCIT ID C165776


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Revumenib + Venetoclax Azacitidine Revumenib Venetoclax 0 1
Cytarabine + Daunorubicin + Midostaurin + Revumenib Cytarabine Daunorubicin Midostaurin Revumenib 0 0
Cytarabine + Daunorubicin + Revumenib Cytarabine Daunorubicin Revumenib 0 2
Cytarabine + Idarubicin + Revumenib Cytarabine Idarubicin Revumenib 0 1
Cytarabine + Midostaurin + Revumenib Cytarabine Midostaurin Revumenib 0 0
Gilteritinib + Revumenib Gilteritinib Revumenib 0 1
Revumenib Revumenib 3 9
Revumenib + Venetoclax Revumenib Venetoclax 1 1

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