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Drug Name Glofitamab-gxbm
Trade Name Columvi
Synonyms RO 7082859|RO-7082859|RO7082859
Drug Descriptions

Columvi (glofitamab-gxbm) is a bispecific antibody that binds the tumor-associated antigen, MS4A1 (CD20), and CD3 on T-cells to stimulate T-cell killing of CD20-expressing tumor cells (PMID: 36507690). Columvi (glofitamab-gxbm) is FDA-approved for use in patients with relapsed or refractory diffuse large B-cell lymphoma, not otherwise specified or large B-cell lymphoma (LBCL) arising from follicular lymphoma, after two or more lines of systemic therapy (FDA.gov).

DrugClasses CD20 Antibody 21 CD3 Antibody 93
CAS Registry Number 2229047-91-8
NCIT ID C148486

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + Glofitamab-gxbm + Obinutuzumab Acalabrutinib Glofitamab-gxbm Obinutuzumab 0 1
Atezolizumab + Glofitamab-gxbm + Obinutuzumab Atezolizumab Glofitamab-gxbm Obinutuzumab 0 1
Atezolizumab + Glofitamab-gxbm + Obinutuzumab + Tocilizumab Atezolizumab Glofitamab-gxbm Obinutuzumab Tocilizumab 0 1
axicabtagene ciloleucel + Glofitamab-gxbm Glofitamab-gxbm axicabtagene ciloleucel 0 1
Carboplatin + Etoposide + Glofitamab-gxbm + Ifosfamide + Obinutuzumab + Rituximab Carboplatin Etoposide Glofitamab-gxbm Ifosfamide Obinutuzumab Rituximab 0 1
Carboplatin + Etoposide + Glofitamab-gxbm + Ifosfamide + Obinutuzumab + Rituximab + Tocilizumab Carboplatin Etoposide Glofitamab-gxbm Ifosfamide Obinutuzumab Rituximab Tocilizumab 0 1
Carboplatin + Etoposide + Glofitamab-gxbm + Ifosfamide + Rituximab Carboplatin Etoposide Glofitamab-gxbm Ifosfamide Rituximab 0 1
CC-99282 + Glofitamab-gxbm CC-99282 Glofitamab-gxbm 0 1
Cyclophosphamide + Doxorubicin + Glofitamab-gxbm + Obinutuzumab + Prednisone + Vincristine Sulfate Cyclophosphamide Doxorubicin Glofitamab-gxbm Obinutuzumab Prednisone Vincristine Sulfate 0 1
Cyclophosphamide + Doxorubicin + Glofitamab-gxbm + Polatuzumab vedotin-piiq + Prednisolone + Rituximab Cyclophosphamide Doxorubicin Glofitamab-gxbm Polatuzumab vedotin-piiq Prednisolone Rituximab 0 1
Cyclophosphamide + Doxorubicin + Glofitamab-gxbm + Polatuzumab vedotin-piiq + Prednisone + Rituximab Cyclophosphamide Doxorubicin Glofitamab-gxbm Polatuzumab vedotin-piiq Prednisone Rituximab 0 2
Cyclophosphamide + Doxorubicin + Glofitamab-gxbm + Prednisolone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Glofitamab-gxbm Prednisolone Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Doxorubicin + Glofitamab-gxbm + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Glofitamab-gxbm Prednisone Rituximab Vincristine Sulfate 0 2
Gemcitabine + Glofitamab-gxbm + Oxaliplatin Gemcitabine Glofitamab-gxbm Oxaliplatin 0 1
Glofitamab-gxbm Glofitamab-gxbm 0 4
Glofitamab-gxbm + Iberdomide Glofitamab-gxbm Iberdomide 0 1
Glofitamab-gxbm + Ibrutinib + Obinutuzumab Glofitamab-gxbm Ibrutinib Obinutuzumab 0 1
Glofitamab-gxbm + Lenalidomide Glofitamab-gxbm Lenalidomide 0 0
Glofitamab-gxbm + Lenalidomide + Obinutuzumab Glofitamab-gxbm Lenalidomide Obinutuzumab 0 1
Glofitamab-gxbm + Lenalidomide + Obinutuzumab + Venetoclax Glofitamab-gxbm Lenalidomide Obinutuzumab Venetoclax 0 1
Glofitamab-gxbm + Obinutuzumab Glofitamab-gxbm Obinutuzumab 0 5
Glofitamab-gxbm + Obinutuzumab + Pirtobrutinib Glofitamab-gxbm Obinutuzumab Pirtobrutinib 0 1
Glofitamab-gxbm + Obinutuzumab + Polatuzumab vedotin-piiq Glofitamab-gxbm Obinutuzumab Polatuzumab vedotin-piiq 0 1
Glofitamab-gxbm + Obinutuzumab + Polatuzumab vedotin-piiq + Rituximab Glofitamab-gxbm Obinutuzumab Polatuzumab vedotin-piiq Rituximab 0 1
Glofitamab-gxbm + Obinutuzumab + Polatuzumab vedotin-piiq + Tocilizumab Glofitamab-gxbm Obinutuzumab Polatuzumab vedotin-piiq Tocilizumab 0 1
Glofitamab-gxbm + Obinutuzumab + RO7227166 + Tocilizumab Glofitamab-gxbm Obinutuzumab RO7227166 Tocilizumab 0 1
Glofitamab-gxbm + Obinutuzumab + RO7443904 Glofitamab-gxbm Obinutuzumab RO7443904 0 1
Glofitamab-gxbm + Obinutuzumab + RO7443904 + Tocilizumab Glofitamab-gxbm Obinutuzumab RO7443904 Tocilizumab 0 1
Glofitamab-gxbm + Obinutuzumab + Tocilizumab Glofitamab-gxbm Obinutuzumab Tocilizumab 0 1
Glofitamab-gxbm + Obinutuzumab + TTI-622 Glofitamab-gxbm Obinutuzumab TTI-622 0 1
Glofitamab-gxbm + Pirtobrutinib Glofitamab-gxbm Pirtobrutinib 0 1
Glofitamab-gxbm + RO7227166 Glofitamab-gxbm RO7227166 0 0
Glofitamab-gxbm + RO7443904 Glofitamab-gxbm RO7443904 0 0
Glofitamab-gxbm + RO7443904 + Tocilizumab Glofitamab-gxbm RO7443904 Tocilizumab 0 0


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