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Drug Name KTE-C19
Trade Name Yescarta
Synonyms KTE-C19 CAR|axicabtagene ciloleucel
Drug Descriptions

Yescarta (KTE-C19) is an immunotherapy consisted of peripheral T-lymphocytes engineered to express a chimeric antigen receptor targeting CD19, CD28 and CD3zeta, resulting in immunostimulating and antineoplastic activities (Blood 2015 126:3991). Yescarta (KTE-C19) is FDA approved for treatment of relapsed or refractory large B-cell lymphoma (FDA.gov).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + KTE-C19 Acalabrutinib KTE-C19 0 1
Atezolizumab + KTE-C19 Atezolizumab KTE-C19 0 1
Cyclophosphamide + Fludarabine + KTE-C19 Cyclophosphamide Fludarabine KTE-C19 0 5
Cyclophosphamide + Fludarabine + KTE-C19 + Lenalidomide Cyclophosphamide Fludarabine KTE-C19 Lenalidomide 0 1
Cyclophosphamide + Fludarabine + KTE-C19 + Rituximab Cyclophosphamide Fludarabine KTE-C19 Rituximab 0 1
KTE-C19 KTE-C19 2 6
KTE-C19 + Utomilumab KTE-C19 Utomilumab 0 1


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