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Drug Name Tisagenlecleucel
Trade Name Kymriah
Synonyms CTL019
Drug Descriptions

Kymriah (tisagenlecleucel) is a preparation of autologous T-lymphocytes engineered to express chimeric antigen receptors targeting CD19-positive cells, resulting in anti-tumor immune response (J Clin Oncol 35, 2017 (suppl; abstr 10523)). Kymriah (tisagenlecleucel) is FDA approved for pediatric and young adult patients with B-cell precursor acute lymphoblastic leukemia, adult patient with relapsed or refractory large B-cell lymphoma, and adult patients with relapsed or refractory follicular lymphoma (FDA.gov).

CAS Registry Number 1823078-37-0
NCIT ID C102758


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Fludarabine + Tisagenlecleucel Bendamustine Fludarabine Tisagenlecleucel 0 1
Cyclophosphamide + Fludarabine + Tisagenlecleucel Cyclophosphamide Fludarabine Tisagenlecleucel 0 3
Ibrutinib + Tisagenlecleucel Ibrutinib Tisagenlecleucel 0 1
Pembrolizumab + Tisagenlecleucel Pembrolizumab Tisagenlecleucel 0 1
Tisagenlecleucel Tisagenlecleucel 0 11

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