Drug Detail


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Drug Name TTI-622
Trade Name
Synonyms PF07901801|PF 07901801|PF-07901801|Maplirpacept|TTI 622|TTI622
Drug Descriptions

TTI-622 is a fusion protein consisting of SIRPa fused to the human IgG4 Fc region, that binds to CD47 and blocks inhibitory signaling to macrophages, resulting in increased phagocytosis of tumor cells (Cancer Res 2018;78(13 Suppl):Abstract nr 2709).

DrugClasses CD47 Antibody 30 Immune Checkpoint Inhibitor 147
CAS Registry Number NA
NCIT ID C150756


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Daratumumab + TTI-622 Daratumumab TTI-622 0 1
Glofitamab-gxbm + Obinutuzumab + TTI-622 Glofitamab-gxbm Obinutuzumab TTI-622 0 1
Lenalidomide + Tafasitamab-cxix + TTI-622 Lenalidomide TTI-622 Tafasitamab-cxix 0 1
Pegylated liposomal doxorubicin + TTI-622 Pegylated liposomal doxorubicin TTI-622 0 1
Pembrolizumab + TTI-622 Pembrolizumab TTI-622 0 1
TTI-622 TTI-622 0 1

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