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Drug Name AZD9150
Trade Name
Synonyms ISIS 481464|ISIS-STAT3rx|Danvatirsen
Drug Descriptions

ISIS-STAT3rx (AZD9150) is an antisense oligonucleotide that inhibits translation of STAT3, which is often activated by receptor tyrosine kinases including FGFR, thereby preventing cell proliferation (PMID: 23935373, PMID: 30661177).

DrugClasses STAT3 Inhibitor 23
CAS Registry Number 1402357-06-5
NCIT ID C101368


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + AZD9150 AZD9150 Acalabrutinib 0 1
AZD9150 AZD9150 0 2
AZD9150 + Carboplatin + Durvalumab AZD9150 Carboplatin Durvalumab 0 0
AZD9150 + Carboplatin + Durvalumab + Gemcitabine AZD9150 Carboplatin Durvalumab Gemcitabine 0 1
AZD9150 + Carboplatin + Durvalumab + Nab-paclitaxel AZD9150 Carboplatin Durvalumab Nab-paclitaxel 0 1
AZD9150 + Cisplatin + Durvalumab AZD9150 Cisplatin Durvalumab 0 0
AZD9150 + Cisplatin + Durvalumab + Fluorouracil AZD9150 Cisplatin Durvalumab Fluorouracil 0 1
AZD9150 + Cisplatin + Durvalumab + Gemcitabine AZD9150 Cisplatin Durvalumab Gemcitabine 0 1
AZD9150 + Durvalumab AZD9150 Durvalumab 0 8
AZD9150 + Durvalumab + Gemcitabine AZD9150 Durvalumab Gemcitabine 0 0
AZD9150 + Durvalumab + Nab-paclitaxel AZD9150 Durvalumab Nab-paclitaxel 0 0
AZD9150 + Durvalumab + Paclitaxel AZD9150 Durvalumab Paclitaxel 0 0
AZD9150 + Durvalumab + Pemetrexed Disodium AZD9150 Durvalumab Pemetrexed Disodium 0 0
AZD9150 + Selumetinib AZD9150 Selumetinib 0 0

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