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Drug Name Rituximab Hyaluronidase
Trade Name
Synonyms Rituxan Hycela|Rituximab and Hyaluronidase Human|Rituximab/Hyaluronidase
Drug Descriptions

Rituximab Hyaluronidase consists of a preparation of the CD20 antibody Rituxan (rituximab) combined with hyaluronidase, which upon delivery leads to break down of tissue hyaluronan by the hyaluronidase component, resulting in increased rituximab absorption and potentially resulting in enhanced complement-dependent and antibody-dependent cytotoxicity against CD20-positive tumor cells (NCI Drug Dictionary).

DrugClasses CD20 Antibody 12
CAS Registry Number NA
NCIT ID C136821

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + Bortezomib + Cyclophosphamide + Doxorubicin + Prednisone + Rituximab Hyaluronidase Acalabrutinib Bortezomib Cyclophosphamide Doxorubicin Prednisone Rituximab Hyaluronidase 0 1
Acalabrutinib + Cytarabine + Rituximab Hyaluronidase Acalabrutinib Cytarabine Rituximab Hyaluronidase 0 1
Acalabrutinib + Rituximab Hyaluronidase Acalabrutinib Rituximab Hyaluronidase 0 0
Lenalidomide + Rituximab Hyaluronidase + Venetoclax Lenalidomide Rituximab Hyaluronidase Venetoclax 0 1
Polatuzumab vedotin-piiq + Rituximab + Rituximab Hyaluronidase + Venetoclax Polatuzumab vedotin-piiq Rituximab Rituximab Hyaluronidase Venetoclax 0 1
Rituximab Hyaluronidase Rituximab Hyaluronidase 0 0
Rituximab Hyaluronidase + Venetoclax Rituximab Hyaluronidase Venetoclax 0 1


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