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Drug Name Refametinib
Trade Name
Synonyms BAY 869766|BAY 8697661|BAY-869766|BAY-8697661|BAY86-9766|RDEA-119
Drug Descriptions

Refametinib (BAY86-9766) is an inhibitor of MEK1 and MEK2, which prevents growth-factor mediated cell proliferation (PMID: 24204195, PMID: 32314268).

DrugClasses MEK inhibitor (Pan) 22 MEK1 Inhibitor 20 MEK2 Inhibitor 18

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Copanlisib + Refametinib Copanlisib Refametinib 1 1
Gemcitabine + Refametinib Gemcitabine Refametinib 1 0
Refametinib Refametinib 5 1
Refametinib + Regorafenib Refametinib Regorafenib 0 1
Refametinib + Sorafenib Refametinib Sorafenib 4 1


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