Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Refametinib
Trade Name
Synonyms BAY 869766|BAY 8697661|BAY-869766|BAY-8697661|BAY86-9766|RDEA-119|RDEA119
Drug Descriptions

Refametinib (BAY86-9766) is an inhibitor of MEK1 and MEK2, which prevents growth-factor mediated cell proliferation (PMID: 24204195, PMID: 32314268).

DrugClasses MEK inhibitor (Pan) 24 MEK1 Inhibitor 26 MEK2 Inhibitor 24
CAS Registry Number 923032-37-5
NCIT ID C74059


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Copanlisib + Refametinib Copanlisib Refametinib 0 1
Gemcitabine + Refametinib Gemcitabine Refametinib 0 0
Refametinib Refametinib 4 1
Refametinib + Regorafenib Refametinib Regorafenib 0 1
Refametinib + Sorafenib Refametinib Sorafenib 1 1

Additional content available in CKB BOOST