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|Therapy Name||Pertuzumab + TAEK-VAC-HerBy + Trastuzumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Pertuzumab||Perjeta||2C4 Antibody||HER2 (ERBB2) Antibody 64||Perjeta (pertuzumab) is a monoclonal antibody that binds ERBB2 (HER2) to prevent dimerization and subsequent HER signaling, thereby resulting in apoptosis and tumor growth inhibition (PMID: 15699478). Perjeta (pertuzumab) is FDA approved in combination with Herceptin (trastuzumab) and Taxotere (docetaxel) for patients with ERBB2 (HER2)-positive breast cancer and in combination with Herceptin (trastuzumab) and chemotherapy as neoadjuvant treatment for patients with ERBB2 (HER2)-positive breast cancer (FDA.gov).|
|TAEK-VAC-HerBy||TAEK-VAC-HerBy Vaccine||HER2 (ERBB2) Vaccine 12||TAEK-VAC-HerBy is a cancer vaccine targeted against Erbb2 (Her2) receptor on tumor cells, and may lead to inhibition of cell proliferation, induction of a T-cell immune response, and tumor cell killing (NCI Thesaurus).|
|Trastuzumab||Herceptin||Anti HER2||HER2 (ERBB2) Antibody 64||Herceptin (trastuzumab) is a monoclonal antibody, which binds ERBB2 (HER2) to induce tumor cellular cytotoxicity (PMID: 17611206). Herceptin (trastuzumab) is FDA approved for HER2-overexpressing (or amplification) breast cancer, gastric adenocarcinoma, and gastroesophageal junction adenocarcinoma (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04246671||Phase Ib/II||TAEK-VAC-HerBy Pertuzumab + TAEK-VAC-HerBy + Trastuzumab Ado-trastuzumab emtansine + TAEK-VAC-HerBy TAEK-VAC-HerBy + Trastuzumab||TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer||Recruiting||USA||0|