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Drug Name Zotatifin
Trade Name
Synonyms eFT226|eFT-226|eFT 226
Drug Descriptions

Zotatifin (eFT226) is an eukaryotic initiation factor 4A1 (eIF4A1) inhibitor that promotes binding of eIF4A1 to the 5'-UTR in a sequence selective manner, which leads to repression of mRNA translation, including translation of the receptor tyrosine kinases FGFR1/2 and ERBB2 (HER2), and potentially results in induction of apoptosis and inhibition of tumor growth (Mol Cancer Ther 2019;18(12 Suppl):Abstract nr B133, PMID: 32470302).

CAS Registry Number 2098191-53-6
NCIT ID C165746


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Fulvestrant + Zotatifin Abemaciclib Fulvestrant Zotatifin 0 1
Fulvestrant + Zotatifin Fulvestrant Zotatifin 0 1
Sotorasib + Zotatifin Sotorasib Zotatifin 0 1
Trastuzumab + Zotatifin Trastuzumab Zotatifin 0 1
Zotatifin Zotatifin 2 1

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