Drug Detail


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Drug Name XL147
Trade Name
Synonyms SAR245408|Pilaralisib|XL-147
Drug Descriptions

Pilaralisib (XL147) is an inhibitor of all class I PI3Ks, thereby blocking activation of the PI3K signaling pathway and potentially resulting in antitumor activity including inhibition of cell proliferation, cell invasion, and tumor growth (PMID: 25637314, PMID: 29593099).

DrugClasses PI3K Inhibitor (Pan) 40
CAS Registry Number 934526-89-3
NCIT ID C71705


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Paclitaxel + XL147 Carboplatin Paclitaxel XL147 0 0
Carboplatin + XL147 Carboplatin XL147 0 0
Paclitaxel + XL147 Paclitaxel XL147 1 0
Seribantumab + XL147 Seribantumab XL147 0 0
Trastuzumab + XL147 Trastuzumab XL147 0 0
Voxtalisib + XL147 Voxtalisib XL147 0 0
XL147 XL147 9 1

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