Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name XL147
Trade Name
Synonyms SAR245408|Pilaralisib|XL-147
Drug Descriptions

Pilaralisib (XL147) is an inhibitor of all class I PI3Ks, thereby blocking activation of the PI3K signaling pathway and potentially resulting in antitumor activity including inhibition of cell proliferation, cell invasion, and tumor growth (PMID: 25637314, PMID: 29593099).

DrugClasses PI3K Inhibitor (Pan) 40
CAS Registry Number 934526-89-3
NCIT ID C71705


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Paclitaxel + XL147 Carboplatin Paclitaxel XL147 0 0
Carboplatin + XL147 Carboplatin XL147 0 0
Paclitaxel + XL147 Paclitaxel XL147 1 0
Seribantumab + XL147 Seribantumab XL147 0 0
Trastuzumab + XL147 Trastuzumab XL147 0 0
Voxtalisib + XL147 Voxtalisib XL147 0 0
XL147 XL147 9 1

Additional content available in CKB BOOST