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Drug Name SAR245409
Trade Name
Synonyms XL765|Voxtalisib
Drug Descriptions

XL765 (SAR245409) inhibits both PI3K and mTOR kinases and results in inhibition of PI3K pathway signaling, thereby possibly leading to inhibition of cell proliferation, reduced tumor vascularization, and inhibition of tumor growth (PMID: 24634413).

DrugClasses mTOR Inhibitor 51 PI3K Inhibitor (Pan) 37

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Pimasertib + SAR245409 Pimasertib SAR245409 1 0
SAR245409 SAR245409 4 2
SAR245409 + XL147 SAR245409 XL147 0 0


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