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XL765 (SAR245409) inhibits both PI3K and mTOR kinases and results in inhibition of PI3K pathway signaling, thereby possibly leading to inhibition of cell proliferation, reduced tumor vascularization, and inhibition of tumor growth (PMID: 24634413).
|DrugClasses||mTOR Inhibitor 51 PI3K Inhibitor (Pan) 37|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Pimasertib + SAR245409||Pimasertib SAR245409||1||0|
|SAR245409 + XL147||SAR245409 XL147||0||0|