Drug Detail


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Drug Name Seribantumab
Trade Name
Synonyms MM-121|SAR256212
Drug Descriptions

Seribantumab (SAR256212) is a human monoclonal antibody that binds ERBB3 (HER3) and prevents ligand binding and heterodimerization with other ERBB family members, resulting in decreased activation of downstream signaling and potentially leading to reduced tumor growth (PMID: 26310543, PMID: 30975923).

DrugClasses HER3 (ERBB3) Antibody 23
CAS Registry Number 1334296-12-6
NCIT ID C78859


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Erlotinib + Seribantumab Erlotinib Seribantumab 0 0
Exemestane + Seribantumab Exemestane Seribantumab 0 0
Fulvestrant + Seribantumab Fulvestrant Seribantumab 0 1
Letrozole + Seribantumab Letrozole Seribantumab 0 0
Seribantumab Seribantumab 0 3
Seribantumab + XL147 Seribantumab XL147 0 0

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