Drug Detail


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Drug Name Palazestrant
Trade Name
Synonyms OP1250|OP 1250|OP-1250
Drug Descriptions

Palazestrant is a Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD), which blocks the activity of the AF1 and AF2 domains of the estrogen receptor, potentially resulting in decreased cell proliferation and inhibition of tumor growth (PMID: 38102750).

DrugClasses Hormone - Anti-estrogens 25
CAS Registry Number 2092925-89-6
NCIT ID C176877


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Palazestrant Abemaciclib Palazestrant 0 0
Alpelisib + Palazestrant Alpelisib Palazestrant 0 1
Palazestrant Palazestrant 0 2
Palazestrant + Palbociclib Palazestrant Palbociclib 0 1
Palazestrant + Ribociclib Palazestrant Ribociclib 0 1
Palazestrant + Trastuzumab Palazestrant Trastuzumab 0 0
Palazestrant + Tucatinib Palazestrant Tucatinib 0 0

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