Drug Detail


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Drug Name OP-1250
Trade Name
Synonyms OP1250|OP 1250
Drug Descriptions

OP-1250 is a Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD), which blocks the activity of the AF1 and AF2 domains of the estrogen receptor and may inhibit cell proliferation and tumor growth (Cancer Res 2020;80(4 Suppl):Abstract nr P5-05-02).

DrugClasses Hormone - Anti-estrogens 24
CAS Registry Number NA
NCIT ID C176877


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alpelisib + OP-1250 Alpelisib OP-1250 0 1
OP-1250 OP-1250 0 1
OP-1250 + Palbociclib OP-1250 Palbociclib 0 1
OP-1250 + Ribociclib OP-1250 Ribociclib 0 1
OP-1250 + Trastuzumab OP-1250 Trastuzumab 0 0
OP-1250 + Tucatinib OP-1250 Tucatinib 0 0

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