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Drug Name | OP-1250 |
Trade Name | |
Synonyms | OP1250|OP 1250 |
Drug Descriptions |
OP-1250 is a Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD), which blocks the activity of the AF1 and AF2 domains of the estrogen receptor and may inhibit cell proliferation and tumor growth (Cancer Res 2020;80(4 Suppl):Abstract nr P5-05-02). |
DrugClasses | Hormone - Anti-estrogens 24 |
CAS Registry Number | NA |
NCIT ID | C176877 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Alpelisib + OP-1250 | Alpelisib OP-1250 | 0 | 1 |
OP-1250 | OP-1250 | 0 | 1 |
OP-1250 + Palbociclib | OP-1250 Palbociclib | 0 | 1 |
OP-1250 + Ribociclib | OP-1250 Ribociclib | 0 | 1 |
OP-1250 + Trastuzumab | OP-1250 Trastuzumab | 0 | 0 |
OP-1250 + Tucatinib | OP-1250 Tucatinib | 0 | 0 |