Drug Detail


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Drug Name LY3484356
Trade Name
Synonyms LY 3484356|LY-3484356|SERD LY3484356
Drug Descriptions

LY3484356 is selective estrogen receptor degrader that binds to the estrogen receptor (ER) and causes a change in conformation resulting in ER protein degradation, potentially leading to decreased tumor cell growth and survival, and antitumor activity (J Clin Oncol 39, no. 15_suppl (May 20, 2021) 1050-1050; NCI Drug Dictionary).

DrugClasses Hormone - Anti-estrogens 18
CAS Registry Number NA
NCIT ID C174042


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Anastrozole + LY3484356 Abemaciclib Anastrozole LY3484356 0 1
Abemaciclib + Exemestane + LY3484356 Abemaciclib Exemestane LY3484356 0 1
Abemaciclib + Letrozole + LY3484356 Abemaciclib LY3484356 Letrozole 0 1
Abemaciclib + LY3484356 Abemaciclib LY3484356 0 1
Abemaciclib + LY3484356 + Trastuzumab Abemaciclib LY3484356 Trastuzumab 0 1
Alpelisib + LY3484356 Alpelisib LY3484356 0 1
Everolimus + LY3484356 Everolimus LY3484356 0 1
LY3484356 LY3484356 0 3

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