Drug Detail


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Drug Name LOXO-783
Trade Name
Synonyms LOXO 783|LOXO783|LOX-22783|LOX 22783|LOX22783
Drug Descriptions

LOXO-783 (LOX-22783) selectively inhibits PIK3CA H1047R leading to decreased downstream signaling and potentially resulting in tumor growth inhibition (Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P142).

DrugClasses PIK3CA inhibitor 23
CAS Registry Number NA
NCIT ID C187335


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Anastrozole + LOXO-783 Abemaciclib Anastrozole LOXO-783 0 1
Abemaciclib + Exemestane + LOXO-783 Abemaciclib Exemestane LOXO-783 0 1
Abemaciclib + Fulvestrant + LOXO-783 Abemaciclib Fulvestrant LOXO-783 0 1
Abemaciclib + Letrozole + LOXO-783 Abemaciclib LOXO-783 Letrozole 0 1
Abemaciclib + LOXO-783 + LY3484356 Abemaciclib LOXO-783 LY3484356 0 1
Anastrozole + LOXO-783 Anastrozole LOXO-783 0 1
Exemestane + LOXO-783 Exemestane LOXO-783 0 1
Fulvestrant + LOXO-783 Fulvestrant LOXO-783 0 1
Letrozole + LOXO-783 LOXO-783 Letrozole 0 1
LOXO-783 LOXO-783 1 1
LOXO-783 + LY3484356 LOXO-783 LY3484356 0 1
LOXO-783 + Paclitaxel LOXO-783 Paclitaxel 0 1

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