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Therapy Name | LY3484356 |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
LY3484356 | LY 3484356|LY-3484356|SERD LY3484356 | Hormone - Anti-estrogens 22 | LY3484356 is selective estrogen receptor degrader that binds to the estrogen receptor (ER) and causes a change in conformation resulting in ER protein degradation, potentially leading to decreased tumor cell growth and survival, and antitumor activity (J Clin Oncol 39, no. 15_suppl (May 20, 2021) 1050-1050; NCI Drug Dictionary). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT04975308 | Phase III | Exemestane Abemaciclib + LY3484356 LY3484356 Fulvestrant | A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer | Recruiting | USA | ITA | FRA | ESP | DEU | BEL | AUT | 15 |
NCT04647487 | Phase I | LY3484356 | A Study of LY3484356 in Women With Breast Cancer Before Having Surgery (EMBER-2) | Recruiting | USA | FRA | ESP | DEU | BEL | 1 |
NCT04188548 | Phase I | Abemaciclib + LY3484356 LY3484356 Abemaciclib + LY3484356 + Trastuzumab Abemaciclib + Anastrozole + LY3484356 Abemaciclib + Exemestane + LY3484356 Alpelisib + LY3484356 Everolimus + LY3484356 Abemaciclib + Letrozole + LY3484356 | A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer (EMBER) | Recruiting | USA | FRA | ESP | BEL | 4 |