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Drug Name Zenocutuzumab
Trade Name
Synonyms MCLA-128|MCLA128|MCLA 128
Drug Descriptions

Zenocutuzumab (MCLA-128) is a bispecific antibody that targets Erbb2 (Her2) and Erbb3, resulting in antibody-dependent cell-mediated cytotoxicity against tumor cells (Cancer Res 2016;76(14 Suppl):Abstract nr CT050, PMID: 32054397).

DrugClasses HER2 (ERBB2) Antibody 73 HER3 (ERBB3) Antibody 23
CAS Registry Number 1969309-56-5
NCIT ID C152948

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Zenocutuzumab Abiraterone Zenocutuzumab 0 1
Afatinib + Zenocutuzumab Afatinib Zenocutuzumab 0 1
Anastrozole + Zenocutuzumab Anastrozole Zenocutuzumab 0 1
Enzalutamide + Zenocutuzumab Enzalutamide Zenocutuzumab 0 1
Exemestane + Zenocutuzumab Exemestane Zenocutuzumab 0 1
Fulvestrant + Zenocutuzumab Fulvestrant Zenocutuzumab 0 1
Letrozole + Zenocutuzumab Letrozole Zenocutuzumab 0 1
Trastuzumab + Vinorelbine + Zenocutuzumab Trastuzumab Vinorelbine Zenocutuzumab 0 1
Trastuzumab + Zenocutuzumab Trastuzumab Zenocutuzumab 0 1
Zenocutuzumab Zenocutuzumab 0 1


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