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|Therapy Name||Carboplatin + Paclitaxel + Trastuzumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Carboplatin||Paraplatin||CBDCA||Chemotherapy - Platinum 6||Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary).|
|Paclitaxel||Taxol||7-Epipaclitaxel||Antimicrotubule Agent 12 BCL2 Family Inhibitor 6||Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary).|
|Trastuzumab||Herceptin||Anti HER2||HER2 (ERBB2) Antibody 38||Herceptin (trastuzumab) is a monoclonal antibody, which binds ERBB2 (HER2) to induce tumor cellular cytotoxicity (PMID: 17611206). Herceptin (trastuzumab) is FDA approved for HER2-overexpressing (or amplification) breast cancer, gastric adenocarcinoma, and gastroesophageal junction adenocarcinoma (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ERBB2 exon 20 ins||lung non-small cell carcinoma||predicted - sensitive||Carboplatin + Paclitaxel + Trastuzumab||Case Reports/Case Series||Actionable||In a clinical study, treatment with the combination of Herceptin (trastuzumab), Paraplatin (carboplatin), and Taxol (paclitaxel) in non-small cell lung cancer patients harboring an ERBB2 exon 20 insertion (n=2) resulted in a partial response in one patient and stable disease in the other patient (PMID: 23610105).||23610105|
|ERBB2 positive||uterine corpus serous adenocarcinoma||sensitive||Carboplatin + Paclitaxel + Trastuzumab||Guideline||Actionable||Combination Paraplatin (carboplatin), Taxol (paclitaxel), and Herceptin (trastuzumab) is in guidelines for ERBB2 (HER2)-positive patients with advanced and recurrent uterine serous carcinoma (NCCN.org).||detail...|
|ERBB2 over exp||Her2-receptor positive breast cancer||sensitive||Carboplatin + Paclitaxel + Trastuzumab||Guideline||Actionable||Herceptin combined with Paraplatin (carboplatin) and Taxol (paclitaxel) is included in guidelines as systemic therapy for patients with recurrent or metastatic hormone receptor-positive (ER and/or PR) or negative, ERBB2 (HER2)-positive breast cancer (NCCN.org).||detail...|
|ERBB2 amp||Her2-receptor positive breast cancer||sensitive||Carboplatin + Paclitaxel + Trastuzumab||Guideline||Actionable||Herceptin combined with Paraplatin (carboplatin) and Taxol (paclitaxel) is included in guidelines as systemic therapy for patients with recurrent or metastatic hormone receptor-positive (ER and/or PR) or negative, ERBB2 (HER2)-positive breast cancer (NCCN.org).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT01196390||Phase III||Carboplatin + Paclitaxel + Trastuzumab Carboplatin + Paclitaxel||Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer||Active, not recruiting|