Drug Detail


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Drug Name Evorpacept
Trade Name
Synonyms ALX-148|ALX 148|ALX148
Drug Descriptions

Evorpacept (ALX148) is a chimeric protein consisting of the Fc region of immunoglobulin fused to the CD47 SIRPa-binding domain, that blocks the ability of CD47 to bind SIRPa on macrophages thereby promoting phagocytosis of tumor cells (PMID: 28286286), and may also stimulate cytotoxic T-cells (PMID: 29873856).

DrugClasses CD47 Antibody 30 Immune Checkpoint Inhibitor 147
CAS Registry Number NA
NCIT ID C132851


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Evorpacept Atezolizumab Evorpacept 0 1
Azacitidine + Evorpacept Azacitidine Evorpacept 0 1
Azacitidine + Evorpacept + Venetoclax Azacitidine Evorpacept Venetoclax 0 1
Carboplatin + Evorpacept + Fluorouracil + Pembrolizumab Carboplatin Evorpacept Fluorouracil Pembrolizumab 0 1
Cetuximab + Evorpacept + Pembrolizumab Cetuximab Evorpacept Pembrolizumab 0 1
Cisplatin + Evorpacept + Fluorouracil + Pembrolizumab Cisplatin Evorpacept Fluorouracil Pembrolizumab 0 1
Doxorubicin + Evorpacept + Pembrolizumab Doxorubicin Evorpacept Pembrolizumab 0 1
Enfortumab vedotin-ejfv + Evorpacept Enfortumab vedotin-ejfv Evorpacept 0 1
Evorpacept Evorpacept 0 2
Evorpacept + Lenalidomide + Rituximab Evorpacept Lenalidomide Rituximab 0 1
Evorpacept + Paclitaxel + Ramucirumab + Trastuzumab Evorpacept Paclitaxel Ramucirumab Trastuzumab 0 1
Evorpacept + Pembrolizumab Evorpacept Pembrolizumab 0 1
Evorpacept + Rituximab Evorpacept Rituximab 0 0
Evorpacept + Trastuzumab Evorpacept Trastuzumab 0 1
Evorpacept + Trastuzumab deruxtecan Evorpacept Trastuzumab deruxtecan 0 1
Evorpacept + ZW25 Evorpacept ZW25 0 1

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