Drug Detail


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Drug Name ALX148
Trade Name Evorpacept
Synonyms ALX-148|ALX 148
Drug Descriptions

Evorpacept (ALX148) is a chimeric protein consisting of the Fc region of immunoglobulin fused to the CD47 SIRPa-binding domain, that blocks the ability of CD47 to bind SIRPa on macrophages thereby promoting phagocytosis of tumor cells (PMID: 28286286), and may also stimulate cytotoxic T-cells (PMID: 29873856).

DrugClasses CD47 Antibody 16 Immune Checkpoint Inhibitor 136
CAS Registry Number NA
NCIT ID C132851


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Therapy Name Drugs Efficacy Evidence Clinical Trials
ALX148 ALX148 0 1
ALX148 + Atezolizumab ALX148 Atezolizumab 0 1
ALX148 + Azacitidine ALX148 Azacitidine 0 1
ALX148 + Azacitidine + Venetoclax ALX148 Azacitidine Venetoclax 0 1
ALX148 + Carboplatin + Fluorouracil + Pembrolizumab ALX148 Carboplatin Fluorouracil Pembrolizumab 0 1
ALX148 + Cetuximab + Pembrolizumab ALX148 Cetuximab Pembrolizumab 0 1
ALX148 + Cisplatin + Fluorouracil + Pembrolizumab ALX148 Cisplatin Fluorouracil Pembrolizumab 0 1
ALX148 + Lenalidomide + Rituximab ALX148 Lenalidomide Rituximab 0 1
ALX148 + Pembrolizumab ALX148 Pembrolizumab 0 1
ALX148 + Rituximab ALX148 Rituximab 0 0
ALX148 + Trastuzumab ALX148 Trastuzumab 0 1
ALX148 + ZW25 ALX148 ZW25 0 1

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