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Drug Name Aldoxorubicin
Trade Name
Synonyms INNO-206|Doxorubicin-EMCH
Drug Descriptions

Aldoxorubicin (Doxorubicin-EMCH) is a derivative prodrug of doxorubicin that is converted to free doxorubicin within the acidic environment within tumors, and once converted, doxorubicin intercalates DNA, inhibits DNA synthesis and induces apoptosis (PMID: 30936721).

DrugClasses Chemotherapy - Anthracycline 11

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abexinostat + Aldoxorubicin Abexinostat Aldoxorubicin 1 0
Aldoxorubicin Aldoxorubicin 0 5
Aldoxorubicin + ALT-803 + Avelumab + Bevacizumab + Capecitabine + Cyclophosphamide + ETBX-011 + ETBX-021 + ETBX-051 + ETBX-061 + Fluorouracil + Gemcitabine + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Oxaliplatin ALT-803 Aldoxorubicin Avelumab Bevacizumab Capecitabine Cyclophosphamide ETBX-011 ETBX-021 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Gemcitabine Leucovorin Nab-paclitaxel Oxaliplatin haNK cells 0 2
Aldoxorubicin + ALT-803 + Avelumab + Capecitabine + Cetuximab + Cyclophosphamide + ETBX-011 + ETBX-021 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Oxaliplatin + Regorafenib + Trastuzumab ALT-803 Aldoxorubicin Avelumab Capecitabine Cetuximab Cyclophosphamide ETBX-011 ETBX-021 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Leucovorin Nab-paclitaxel Oxaliplatin Regorafenib Trastuzumab haNK cells 0 1
Aldoxorubicin + ALT-803 + Avelumab + Capecitabine + Cetuximab + Cyclophosphamide + ETBX-011 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Sorafenib ALT-803 Aldoxorubicin Avelumab Capecitabine Cetuximab Cyclophosphamide ETBX-011 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Leucovorin Nab-paclitaxel Sorafenib haNK cells 0 1
Aldoxorubicin + ALT-803 + Avelumab + Cetuximab + ETBX-051 + ETBX-061 + GI-6301 + haNK cells ALT-803 Aldoxorubicin Avelumab Cetuximab ETBX-051 ETBX-061 GI-6301 haNK cells 0 1
Aldoxorubicin + ALT-803 + Avelumab + Cisplatin + Cyclophosphamide + ETBX-011 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6301 + haNK cells + Paclitaxel ALT-803 Aldoxorubicin Avelumab Cisplatin Cyclophosphamide ETBX-011 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6301 Paclitaxel haNK cells 0 1
Aldoxorubicin + ALT-803 + Avelumab + Cyclophosphamide + ETBX-011 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel ALT-803 Aldoxorubicin Avelumab Cyclophosphamide ETBX-011 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Leucovorin Nab-paclitaxel haNK cells 0 1
Aldoxorubicin + ALT-803 + Cyclophosphamide + Gemcitabine + Nab-paclitaxel ALT-803 Aldoxorubicin Cyclophosphamide Gemcitabine Nab-paclitaxel 0 1
Aldoxorubicin + ALT-803 + Cyclophosphamide + Gemcitabine + Nab-paclitaxel + PD-L1.t-haNK ALT-803 Aldoxorubicin Cyclophosphamide Gemcitabine Nab-paclitaxel PD-L1.t-haNK 0 1
Aldoxorubicin + Alvocidib Aldoxorubicin Alvocidib 1 0
Aldoxorubicin + B02 Aldoxorubicin B02 0 0
Aldoxorubicin + Bendamustine + Bortezomib Aldoxorubicin Bendamustine Bortezomib 0 0
Aldoxorubicin + Buparlisib Aldoxorubicin Buparlisib 1 0
Aldoxorubicin + Cisplatin + Cyclophosphamide + Dexamethasone + Etoposide Aldoxorubicin Cisplatin Cyclophosphamide Dexamethasone Etoposide 0 1
Aldoxorubicin + Cisplatin + Filgrastim + Methotrexate + Vinblastine Aldoxorubicin Cisplatin Filgrastim Methotrexate Vinblastine 0 1
Aldoxorubicin + Cisplatin + Methotrexate + Vincristine Sulfate Aldoxorubicin Cisplatin Methotrexate Vincristine Sulfate 0 1
Aldoxorubicin + Cyclophosphamide + Gemcitabine + Nab-paclitaxel Aldoxorubicin Cyclophosphamide Gemcitabine Nab-paclitaxel 0 1
Aldoxorubicin + Cyclophosphamide + Prednisone + Rituximab + Vincristine Sulfate Aldoxorubicin Cyclophosphamide Prednisone Rituximab Vincristine Sulfate 0 1
Aldoxorubicin + Cyclophosphamide + Veliparib Aldoxorubicin Cyclophosphamide Veliparib 0 1
Aldoxorubicin + Dactolisib Aldoxorubicin Dactolisib 1 0
Aldoxorubicin + Docetaxel + Estramustine + Ketoconazole Aldoxorubicin Docetaxel Estramustine Ketoconazole 0 1
Aldoxorubicin + Durvalumab + Motolimod Aldoxorubicin Durvalumab Motolimod 0 1
Aldoxorubicin + Ganetespib Aldoxorubicin Ganetespib 0 1
Aldoxorubicin + Metformin Aldoxorubicin Metformin 1 0
Aldoxorubicin + Rigosertib Aldoxorubicin Rigosertib 1 0
Aldoxorubicin + Seliciclib Aldoxorubicin Seliciclib 0 0


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